U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 20:13:00 GMT 2025
Edited
by admin
on Tue Apr 01 20:13:00 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
TB2Q79LBS0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BP-35
Preferred Name English
B-LYMPHOCYTE ANTIGEN CD20
Common Name English
CD-20
Code English
B-LYMPHOCYTE SURFACE ANTIGEN B1
Common Name English
LEUKOCYTE SURFACE ANTIGEN LEU-16
Common Name English
CD20
Common Name English
MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 1
Common Name English
Code System Code Type Description
IUPHAR
2628
Created by admin on Tue Apr 01 20:13:00 GMT 2025 , Edited by admin on Tue Apr 01 20:13:00 GMT 2025
PRIMARY
SMS_ID
100000177280
Created by admin on Tue Apr 01 20:13:00 GMT 2025 , Edited by admin on Tue Apr 01 20:13:00 GMT 2025
PRIMARY
UNIPROT
P11836
Created by admin on Tue Apr 01 20:13:00 GMT 2025 , Edited by admin on Tue Apr 01 20:13:00 GMT 2025
PRIMARY
FDA UNII
TB2Q79LBS0
Created by admin on Tue Apr 01 20:13:00 GMT 2025 , Edited by admin on Tue Apr 01 20:13:00 GMT 2025
PRIMARY
From To
1_167 1_183
Related Record Type Details
LIGAND->TARGET
BINDING
INHIBITOR -> TARGET
LIGAND->TARGET
BINDING
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Fc-glycans are homogenously engineered onto the antibody and increase ADCC, anti-tumor activity and the half-life of the antibody.
LIGAND->TARGET
BINDING
INHIBITOR -> TARGET
LIGAND->TARGET
LIGAND->TARGET
TRU-015 depletes B-cells from the peripheral blood in vitro, and can mediate complement-and antibody-dependent cellular cytotoxicity.
RADIOLIGAND->TARGET
LIGAND->TARGET
BINDING
INHIBITOR -> TARGET
LIGAND->TARGET
BINDING
CYTOTOXIC T-CELL->TARGET
LIGAND->TARGET
BINDING
ACTIVATOR -> TARGET
CPO107 is to bind to CD20 on the target cell surface to induce the antibody-dependent cellmediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)
IN-VIVO
LIGAND->TARGET
BINDING
CYTOTOXIC T-CELL->TARGET
secrete interferon gamma in response to CD19 and CD20 expressing tumour cell lines
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
IN-VITRO
ANTIGEN->TARGET
CYTOTOXIC T-CELL->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
BINDING
LIGAND->TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
LIGAND->TARGET
LIGAND->TARGET
LIGAND->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_36] [1_225] SERINE DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_111] [1_220] CYSTEINE Amount: S-PALMITOYL CYSTEINE 08WQ73S7SV
AMINO ACID SUBSTITUTION [1_239] THREONINE THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL