Rondecabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 19:32:23 GMT 2025` Edited by `admin` on `Wed Apr 02 19:32:23 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	CELLS
Fraction Name	cd62L entriched t cells
Record UNII	YRT2H8MH4G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

autologous T lymphocytes obtained by leukapheresis enriched for the cell surface marker CD62L (also known as L-selectin) transduced with a self-inactivating non-replicating lentiviral vector encoding a tandem chimeric antigen receptor (CAR) targeting bot

Preferred Name

English

Rondecabtagene Autoleucel

Official Name

English

rondecabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

YRT2H8MH4G

Created by admin on Wed Apr 02 19:32:23 GMT 2025 , Edited by admin on Wed Apr 02 19:32:23 GMT 2025

PRIMARY

INN

13527

Created by admin on Wed Apr 02 19:32:23 GMT 2025 , Edited by admin on Wed Apr 02 19:32:23 GMT 2025

PRIMARY

Related Record Type Details


					TB2Q79LBS0

B-LYMPHOCYTE ANTIGEN CD20

TARGET->CYTOTOXIC T-CELL

Amount:


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					YRT2H8MH4G

Rondecabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS	TRANSFECTION	GENE MODIFICATION	Rondecabtagene autoleucel lentiviral vector	3W8NQ6JLF9
CULTURE	ACTIVATOR	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	ACTIVATOR	BIOLOGICAL	INTERLEUKIN 15, RECOMBINANT NON-GLYCOSYLATED	6D6TDU4V9X

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Rondecabtagene autoleucel transgene insert encoding CD19/CD20 CAR	V8N57C54TG
VECTOR EXPRESSED PROTEIN					Rondecabtagene autoleucel expressed bispecific chimeric antigen receptor targeting CD19 and CD20	UY8S3296EQ

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`G75G5XNC3C` L-SELECTIN

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`IYZ9TI08W3` B-LYMPHOCYTE ANTIGEN CD19