ZUBERITAMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:49:45 GMT 2025` Edited by `admin` on `Wed Apr 02 06:49:45 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	RAT CHIMERIC
Sequence Type	COMPLETE
Record UNII	P1DFX74SQ8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZUBERITAMAB

Official Name

English

zuberitamab [INN]

Preferred Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD20 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL HS006 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL HS006 .KAPPA.-CHAIN, DIMER

Common Name

English

HS-006

Code

English

GAMMA1 HEAVY CHAIN CHIMERIC (1-452) (VH (MUS MUSCULUS IGHV1-12*01(96.9%)-(IGHD)-IGHJ1*03 (100%)/HOMO SAPIENS IGHV1-46*01 (70.4%)-(IGHD)-IGHJ1*03 (85.7%)) (8.8.15) (1-122)-HOMO SAPIENSIGHG1*01 (100%) G1M17,1 (CH1 K120 (219) (123-220), HINGE 1-15 (221-235)

Common Name

English

RHCACD20MA

Code

English

HS006

Code

English

Zuberitamab [WHO-DD]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C174825

Created by admin on Wed Apr 02 06:49:45 GMT 2025 , Edited by admin on Wed Apr 02 06:49:45 GMT 2025

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SMS_ID

300000024176

Created by admin on Wed Apr 02 06:49:45 GMT 2025 , Edited by admin on Wed Apr 02 06:49:45 GMT 2025

PRIMARY

FDA UNII

P1DFX74SQ8

Created by admin on Wed Apr 02 06:49:45 GMT 2025 , Edited by admin on Wed Apr 02 06:49:45 GMT 2025

PRIMARY

CAS

2251143-19-6

Created by admin on Wed Apr 02 06:49:45 GMT 2025 , Edited by admin on Wed Apr 02 06:49:45 GMT 2025

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INN

11331

Created by admin on Wed Apr 02 06:49:45 GMT 2025 , Edited by admin on Wed Apr 02 06:49:45 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_149	2_205
2_225	4_213
2_266	2_326
1_149	1_205
2_372	2_430
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193
1_225	3_213
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					TB2Q79LBS0

B-LYMPHOCYTE ANTIGEN CD20

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					P1DFX74SQ8

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL