EPCORITAMAB

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:49:06 GMT 2023` Edited by `admin` on `Sat Dec 16 14:49:06 GMT 2023`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	D6OMY2L0WA
Record Status	`Validated (UNII)`
Record Version

Download

Related Record Type

ALTERNATIVE DEFINITION for [EPCORITAMAB]

Alternative Definition

Name

Type

Language

EPCORITAMAB

Official Name

English

epcoritamab [INN]

Common Name

English

EPCORITAMAB [USAN]

Common Name

English

Epcoritamab [WHO-DD]

Common Name

English

Immunoglobulin G1-lambda/kappa, anti-[Homo sapiens CD3E (CD3 epsilon)] and anti-[Homo sapiens MS4A1 (membrane-spanning 4-domains subfamily A member 1, CD20)], monoclonal bispecific antibody; gamma1 heavy chain chimeric anti-CD3E (1-454) [VH (Mus musculus

Common Name

English

Immunoglobulin G1 [234-phenylalanine, 235-glutamic acid, 265-alanine, 405-leucine], anti-(human CD3 antigen) (human-Mus musculus monoclonal IgG1-huCACAO-FEAL γ1-chain), disulfide with human-Mus musculus monoclonal IgG1-huCACAO-FEAL λ-chain, (234→231'

Common Name

English

GEN-3013

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

865921

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

Code System Code Type Description

CAS

2134641-34-0

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

PRIMARY

INN

11078

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

PRIMARY

USAN

KL-92

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

PRIMARY

NCI_THESAURUS

C163022

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

PRIMARY

FDA UNII

D6OMY2L0WA

Created by admin on Sat Dec 16 14:49:06 GMT 2023 , Edited by admin on Sat Dec 16 14:49:06 GMT 2023

PRIMARY

From	To
1_22	1_98
1_152	1_208
1_228	3_214
1_234	2_231
1_237	2_234
1_269	1_329
1_375	1_433
2_22	2_96
2_149	2_205
2_225	4_214
2_266	2_326
2_372	2_430
3_22	3_90
3_137	3_196
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_302

Related Record Type Details

Epcoritamab-BYSP

SUB_CONCEPT->SUBSTANCE

Amount:


					TB2Q79LBS0

B-LYMPHOCYTE ANTIGEN CD20

TARGET->LIGAND

Comments:

The Sponsor hypothesizes induction of cytotoxicity by GEN3013 is dependent on binding to both CD3 and CD20. By co-engaging CD3 on T cells and CD20 on B cells or tumor cells, GEN3013 induces cytotoxic synapse formation and killing of CD20-positive target cells, independent of ligation of a peptide-major histocompatibility complex (MHC) complex by the T-cell receptor (TCR).

Qualification:

Kd

Amount:


					1U72JD9DDZ

T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN

TARGET -> ACTIVATOR

Qualification:

Kd

Amount:

Related Record Type Details


					D6OMY2L0WA

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL