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Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 22:57:19 UTC 2021
Edited
by admin
on Sat Jun 26 22:57:19 UTC 2021
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
D6OMY2L0WA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPCORITAMAB
INN  
Official Name English
EPCORITAMAB [INN]
Common Name English
IMMUNOGLOBULIN G1 (234-PHENYLALANINE, 235-GLUTAMIC ACID, 265-ALANINE, 405-LEUCINE), ANTI-(HUMAN CD3 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL IGG1-HUCACAO-FEAL .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL IGG1-HUCACAO-FEAL .LAMBDA.-CHAIN,
Systematic Name English
Code System Code Type Description
INN
11078
Created by admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
PRIMARY
NCI_THESAURUS
C163022
Created by admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
PRIMARY
FDA UNII
D6OMY2L0WA
Created by admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
PRIMARY
From To
1_22 1_98
1_152 1_208
1_228 3_214
1_234 2_231
1_237 2_234
1_269 1_329
1_375 1_433
2_22 2_96
2_149 2_205
2_225 4_214
2_266 2_326
2_372 2_430
3_22 3_90
3_137 3_196
4_23 4_88
4_134 4_194
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_305
N 2_302
Related Record Type Details
TARGET->LIGAND
The Sponsor hypothesizes induction of cytotoxicity by GEN3013 is dependent on binding to both CD3 and CD20. By co-engaging CD3 on T cells and CD20 on B cells or tumor cells, GEN3013 induces cytotoxic synapse formation and killing of CD20-positive target cells, independent of ligation of a peptide-major histocompatibility complex (MHC) complex by the T-cell receptor (TCR).
Kd
TARGET -> ACTIVATOR
Kd
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL