Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Jun 26 22:57:19 UTC 2021
by
admin
on
Sat Jun 26 22:57:19 UTC 2021
|
Protein Type | BISPECIFIC ANTIBODY |
Protein Sub Type | IGG1 |
Sequence Origin | HUMANIZED MOUSE |
Sequence Type | COMPLETE |
Record UNII |
D6OMY2L0WA
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
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Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
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11078
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY | |||
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C163022
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY | |||
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D6OMY2L0WA
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY |
From | To |
---|---|
1_22 | 1_98 |
1_152 | 1_208 |
1_228 | 3_214 |
1_234 | 2_231 |
1_237 | 2_234 |
1_269 | 1_329 |
1_375 | 1_433 |
2_22 | 2_96 |
2_149 | 2_205 |
2_225 | 4_214 |
2_266 | 2_326 |
2_372 | 2_430 |
3_22 | 3_90 |
3_137 | 3_196 |
4_23 | 4_88 |
4_134 | 4_194 |
Glycosylation Type | MAMMALIAN |
Glycosylation Link Type | Site |
---|---|
N | 1_305 |
N | 2_302 |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TARGET->LIGAND |
The Sponsor hypothesizes induction of cytotoxicity by GEN3013 is dependent on binding to both CD3 and CD20. By co-engaging CD3 on T cells and CD20 on B cells or tumor cells, GEN3013 induces cytotoxic synapse formation and killing of CD20-positive target cells, independent of ligation of a peptide-major histocompatibility complex (MHC) complex by the T-cell receptor (TCR).
Kd
|
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TARGET -> ACTIVATOR |
Kd
|
Related Record | Type | Details | ||
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ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Molecular Formula | CHEMICAL |
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MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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