Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Jun 26 22:57:19 UTC 2021
by
admin
on
Sat Jun 26 22:57:19 UTC 2021
|
| Protein Type | BISPECIFIC ANTIBODY |
| Protein Sub Type | IGG1 |
| Sequence Origin | HUMANIZED MOUSE |
| Sequence Type | COMPLETE |
| Record UNII |
D6OMY2L0WA
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
11078
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY | |||
|
C163022
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY | |||
|
D6OMY2L0WA
Created by
admin on Sat Jun 26 22:57:19 UTC 2021 , Edited by admin on Sat Jun 26 22:57:19 UTC 2021
|
PRIMARY |
| From | To |
|---|---|
| 1_22 | 1_98 |
| 1_152 | 1_208 |
| 1_228 | 3_214 |
| 1_234 | 2_231 |
| 1_237 | 2_234 |
| 1_269 | 1_329 |
| 1_375 | 1_433 |
| 2_22 | 2_96 |
| 2_149 | 2_205 |
| 2_225 | 4_214 |
| 2_266 | 2_326 |
| 2_372 | 2_430 |
| 3_22 | 3_90 |
| 3_137 | 3_196 |
| 4_23 | 4_88 |
| 4_134 | 4_194 |
| Glycosylation Type | MAMMALIAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_305 |
| N | 2_302 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
TARGET->LIGAND |
The Sponsor hypothesizes induction of cytotoxicity by GEN3013 is dependent on binding to both CD3 and CD20. By co-engaging CD3 on T cells and CD20 on B cells or tumor cells, GEN3013 induces cytotoxic synapse formation and killing of CD20-positive target cells, independent of ligation of a peptide-major histocompatibility complex (MHC) complex by the T-cell receptor (TCR).
Kd
|
||
|
|
TARGET -> ACTIVATOR |
Kd
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
|
||||
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|