Sersacabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 20:31:45 GMT 2025` Edited by `admin` on `Wed Apr 02 20:31:45 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood cell
Fraction Material Type	CELLS
Fraction Name	CD4+/CD8+ enriched T cells
Record UNII	4PM5Q6QW35
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sersacabtagene Autoleucel

Official Name

English

autologous CD4+/CD8+ enriched T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating lentiviral vector encoding a humanized chimeric antigen receptor (CAR) targeting CD20 that includes a CD8? signal

Preferred Name

English

sersacabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

INN

13437

Created by admin on Wed Apr 02 20:31:45 GMT 2025 , Edited by admin on Wed Apr 02 20:31:45 GMT 2025

PRIMARY

FDA UNII

4PM5Q6QW35

Created by admin on Wed Apr 02 20:31:45 GMT 2025 , Edited by admin on Wed Apr 02 20:31:45 GMT 2025

PRIMARY

Related Record Type Details


					TB2Q79LBS0

B-LYMPHOCYTE ANTIGEN CD20

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					4PM5Q6QW35

Sersacabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CULTURE	EXPANSION	BIOLOGICAL	ALDESLEUKIN	M89N0Q7EQR
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION	Sersacabtagene autoleucel vector	BTH2U66BY2

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Sersacabtagene autoleucel transgene insert encoding anti-CD20 humanized chimeric antigen receptor	2A2SQ4C99U
VECTOR EXPRESSED PROTEIN					Sersacabtagene autoleucel expressed anti-CD20 humanized chimeric antigen receptor	H2D45QLE4Y

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`FOR10CZY15` RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
ANTIGEN EXPRESSED	BIOLOGICAL		`ZLW14X2D30` CD3