Prizloncabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:45:57 GMT 2025` Edited by `admin` on `Wed Apr 02 17:45:57 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	enriched for cd4/cd8 t cells
Record UNII	35X9XB2HBG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Prizloncabtagene Autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a bispecific chimeric antigen receptor targeting CD19 and CD20. The expressed transgene

Preferred Name

English

prizloncabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

INN

12614

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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SMS_ID

300000050080

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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NCI_THESAURUS

C178452

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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FDA UNII

35X9XB2HBG

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Comments:

secrete interferon gamma in response to CD19 and CD20 expressing tumour cell lines

Amount:


					TB2Q79LBS0

B-LYMPHOCYTE ANTIGEN CD20

TARGET->CYTOTOXIC T-CELL

Comments:

secrete interferon gamma in response to CD19 and CD20 expressing tumour cell lines

Amount:

Related Record Type Details


					35X9XB2HBG

Prizloncabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Prizloncabtagene autoleucel lentiviral vector	7U3LP6FWC7
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Prizloncabtagene autoleucel transgene insert	BGW3U6F3Z7
VECTOR EXPRESSED PROTEIN					Prizloncabtagene autoleucel expressed bispecific chimeric antigen receptor targeting CD19 and CD20	58B5YT3X5P