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Search results for nonoxynol root_codes_code in Code Literal (approximate match)
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Parbendazole is a potent inhibitor of microtubule assembly that was studied as an anthelmintic agent. Information about the current use of this drug is not available.
Status:
Investigational
Source:
NCT04586790: Phase 2 Interventional Unknown status Spinal Shock
(2020)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Norepinephrine hydrochloride, (±)- (DL-Norepinephrine Hydrochloride) is a vasoconstrictor, cardiac stimulant, α- and β-sympathomimetic agent. DL-Norepinephrine hydrochloride is an adrenergic drug. Norepinephrine is an endogenous catecholamine that is the neurotransmitter at sympathetic postganglionic fibers. It has potent beta1- and alpha-stimulating effects. In contrast to epinephrine, norepinephrine has only minor effects on beta2 receptors. The clinical effects of norepinephrine administration are mainly increased cardiac index and increased vascular (systemic and pulmonary) resistance. Several adult studies have suggested that norepinephrine is useful in increasing SVR in patients with hyperdynamic or vasodilatory septic shock that is not responsive to dopamine or epinephrine. Additionally, it can augment coronary blood flow by increasing systemic diastolic pressure, at the expense of increasing afterload.
Class (Stereo):
CHEMICAL (ABSOLUTE)
FILIPIN is a complex of polyene macrolides obtained from Streptomyces filipinensis. The complex consists of four components: filipin I (4%), II (25%), III (53%), and IV (18%). Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. It is widely used as a marker for detection and quantification of cholesterol in cellular membranes.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Procinonide is a derivative of fluocinolone acetonide that has been applied topically with fluocinonide and ciprocinonide in the management of various skin disorders.
Status:
Investigational
Source:
Diabetes Obes Metab. Mar 2023;25(3):832-843.: Phase 2 Human clinical trial Completed Diabetes Mellitus, Type 2/complications
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Investigational
Source:
INN:dexpropranolol [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(R)-(+)-Propranolol (also known as DEXPROPRANOLOL) is the less active enantiomer of propranolol and is an antagonist of the beta-adrenergic receptor. It is known, that propranolol had been used for myocardial infarction; arrhythmia, anxiety and some other disease, but adverse effects instigated the replacement by newer drugs.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Intrazole (also known as BL-R743) is an indole derivative patented by Bristol-Myers Co and studied for Fungal infections treatment. In preclinical modes Intrazole shows anti-inflammatory activity in intact and adrenalectomized animals, employing the foot edema assay. Intrazole increased the antiinflammatory effect of hydrocortisone in the granuloma pouch model and effectively inhibited or alleviated adjuvant-induced polyarthritis.
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ACHIRAL)
Thyromedan is a thyroalkanoic acid derivative with hypocholesterolemic activity. In clinical trials, Thyromedan in daily doses of 8 to 32 mg caused a decrease in serum cholesterol levels. The serum total triglycerides and the α- and β-lipoprotein partition of cholesterol and triglycerides were unaffected.
Status:
Investigational
Source:
USAN:THYROXINE I 131 [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Thyroxine I-131 is a radiolabeled thyroid hormone that has been studied as a diagnostic agent for thyroid cancer. In pharmacokinetic studies, Thyroxine I-131 shows broad tissue distribution and 99% of the ingested radiolabeled Thyroxine may be found in the skin, intestines, muscles, blood, bones, liver, and thyroid glands of rats.