PROCINONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H34F2O7
Molecular Weight	508.5515
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]4(F)[C@@]2([H])C[C@H](F)C5=CC(=O)C=C[C@]45C

InChI

InChIKey=UBOIMZIXNXGQOH-RTWVSBIPSA-N

InChI=1S/C27H34F2O7/c1-6-22(33)34-13-20(32)27-21(35-23(2,3)36-27)11-15-16-10-18(28)17-9-14(30)7-8-24(17,4)26(16,29)19(31)12-25(15,27)5/h7-9,15-16,18-19,21,31H,6,10-13H2,1-5H3/t15-,16-,18-,19-,21+,24-,25-,26-,27+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H34F2O7
Molecular Weight	508.5515
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.drugfuture.com/mt/tetracosactide.pdf | https://www.ncbi.nlm.nih.gov/pubmed/752447 | https://www.ncbi.nlm.nih.gov/pubmed/6853627

Procinonide is a derivative of fluocinolone acetonide that has been applied topically with fluocinonide and ciprocinonide in the management of various skin disorders.

Originator

Approval Year

PubMed

Title	Date	PubMed
The use of mixtures of topical corticosteroids as a mechanism for improving total drug bioavailability: a preliminary report.	1978	752447

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:24 GMT 2023`
Record UNII	D04S7VLM8Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROCINONIDE

Official Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6,9-DIFLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-21-(1-OXOPROPOXY)-, (6.ALPHA.,11.BETA.,16.ALPHA)-

Common Name

English

6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-propionate

Common Name

English

PROCINONIDE [USAN]

Common Name

English

procinonide [INN]

Common Name

English

RS-2362

Code

English

PROCINONIDE [MART.]

Common Name

English

Procinonide [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521