Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.3434 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NC[C@@H](O)COC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=AQHHHDLHHXJYJD-CQSZACIVSA-N
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.3434 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
(R)-(+)-Propranolol (also known as DEXPROPRANOLOL) is the less active enantiomer of propranolol and is an antagonist of the beta-adrenergic receptor. It is known, that propranolol had been used for myocardial infarction; arrhythmia, anxiety and some other disease, but adverse effects instigated the replacement by newer drugs.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. | 1999 Dec |
|
| KCNQ1 and KCNH2 mutations associated with long QT syndrome in a Chinese population. | 2002 Dec |
|
| The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices. | 2002 Nov |
|
| Renal mechanisms involved in stress-induced antinatriuresis and antidiuresis in rats. | 2003 Jul |
|
| Solubilization of cationic drugs in lung surfactant. | 2003 Nov |
|
| Catecholaminergic consolidation of motor cortical neuroplasticity in humans. | 2004 Nov |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Insights into cyclodextrin interactions during sample stacking using capillary isotachophoresis with on-line microcoil NMR detection. | 2005 Sep |
Patents
Sample Use Guides
in cats: received an intravenous infusion of (+)-propranolol at 0.5 mg/min exhibited a prompt return to sinus rhythm after a mean total dose of 6.5 + 0.9 mg/kg. The final heart rate was an average of 48 beats/min below the initial rate. The difference between the antiarrhythmic doses of (+)- and (- )-propranolol was statistically significant (P<0.01).
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 15:19:07 UTC 2023
by
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Fri Dec 15 15:19:07 UTC 2023
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| Record UNII |
PG6KY07UD7
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| Record Status |
Validated (UNII)
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C29576
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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RACEMATE -> ENANTIOMER |
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ACTIVE MOIETY |
