Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.3434 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NC[C@@H](O)COC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=AQHHHDLHHXJYJD-CQSZACIVSA-N
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.3434 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
(R)-(+)-Propranolol (also known as DEXPROPRANOLOL) is the less active enantiomer of propranolol and is an antagonist of the beta-adrenergic receptor. It is known, that propranolol had been used for myocardial infarction; arrhythmia, anxiety and some other disease, but adverse effects instigated the replacement by newer drugs.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. | 1968 Sep |
|
| The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices. | 2002 Nov |
|
| Evaluation of endoscopic variceal ligation (EVL) versus propanolol plus isosorbide mononitrate/nadolol (ISMN) in the prevention of variceal rebleeding: comparison of cirrhotic and noncirrhotic patients. | 2005 Aug |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine. | 2005 Oct 3 |
Patents
Sample Use Guides
in cats: received an intravenous infusion of (+)-propranolol at 0.5 mg/min exhibited a prompt return to sinus rhythm after a mean total dose of 6.5 + 0.9 mg/kg. The final heart rate was an average of 48 beats/min below the initial rate. The difference between the antiarrhythmic doses of (+)- and (- )-propranolol was statistically significant (P<0.01).
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:19:07 GMT 2023
by
admin
on
Fri Dec 15 15:19:07 GMT 2023
|
| Record UNII |
PG6KY07UD7
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C29576
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
8736
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
21138
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
PRIMARY | |||
|
CHEMBL275742
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
5051-22-9
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
DB03322
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
100000083431
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
PRIMARY | |||
|
SUB07044MIG
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
DTXSID3045304
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
225-749-2
Created by
admin on Fri Dec 15 15:19:07 GMT 2023 , Edited by admin on Fri Dec 15 15:19:07 GMT 2023
|
PRIMARY | |||
|
2638
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
PRIMARY | |||
|
C77944
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
PRIMARY | |||
|
PG6KY07UD7
Created by
admin on Fri Dec 15 15:19:08 GMT 2023 , Edited by admin on Fri Dec 15 15:19:08 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT | |||
|
|
RACEMATE -> ENANTIOMER |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
