THYROXINE I-131

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H11I4NO4
Molecular Weight	792.8766
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC1=CC([131I])=C(OC2=CC([131I])=C(O)C([131I])=C2)C([131I])=C1)C(O)=O

InChI

InChIKey=XUIIKFGFIJCVMT-LRAKGTFSSA-N

InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1/i16+4,17+4,18+4,19+4

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5916836 | https://www.ncbi.nlm.nih.gov/pubmed/4219253 | https://www.tandfonline.com/doi/abs/10.1080/10256018208544739

Thyroxine I-131 is a radiolabeled thyroid hormone that has been studied as a diagnostic agent for thyroid cancer. In pharmacokinetic studies, Thyroxine I-131 shows broad tissue distribution and 99% of the ingested radiolabeled Thyroxine may be found in the skin, intestines, muscles, blood, bones, liver, and thyroid glands of rats.

Originator

Approval Year

PubMed

Title	Date	PubMed
Preparation of I-131-tyrosines and I-131-thyroxine.	1966-02	5916836

Patents

Sample Use Guides

In Vivo Use Guide

Wistar Albino Rats: 50— 100mkCi

Route of Administration: Oral

Name

Type

Language

THYROXINE I 131

Preferred Name

English

THYROXINE I-131

Common Name

English

THYROXINE I 131 [USAN]

Common Name

English

L-TYROSINE, O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-, LABELED WITH IODINE-131

Systematic Name

English

THYROXINE (131I)

Common Name

English

THYROXINE, I-131

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1553