INTRAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H12ClN5O
Molecular Weight	337.763
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C(=O)N2C=C(CC3=NN=NN3)C4=C2C=CC=C4

InChI

InChIKey=ZDHHGGFQZRPUSN-UHFFFAOYSA-N

InChI=1S/C17H12ClN5O/c18-13-7-5-11(6-8-13)17(24)23-10-12(9-16-19-21-22-20-16)14-3-1-2-4-15(14)23/h1-8,10H,9H2,(H,19,20,21,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5072404 | https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19670102&CC=NL&NR=6609235A&KC=A | https://www.ncbi.nlm.nih.gov/pubmed/5355568

Intrazole (also known as BL-R743) is an indole derivative patented by Bristol-Myers Co and studied for Fungal infections treatment. In preclinical modes Intrazole shows anti-inflammatory activity in intact and adrenalectomized animals, employing the foot edema assay. Intrazole increased the antiinflammatory effect of hydrocortisone in the granuloma pouch model and effectively inhibited or alleviated adjuvant-induced polyarthritis.

Originator

Approval Year

PubMed

Title	Date	PubMed
Kinetics of solvolysis of intrazole.	1972 Oct	5072404

Patents

Sample Use Guides

In Vivo Use Guide

mice 128 mg/kg, orally

Route of Administration: Oral

Name

Type

Language

INTRAZOLE

Official Name

English

1-(P-CHLOROBENZOYL)-3-(1H-TETRAZOL-5-YLMETHYL)INDOLE

Common Name

English

BL-R 743

Code

English

1H-INDOLE, 1-(4-CHLOROBENZOYL)-3-(1H-TETRAZOL-5-YLMETHYL)-

Systematic Name

English

INTRAZOLE [USAN]

Common Name

English

intrazole [INN]

Common Name

English

BL-R-743

Code

English

Code System Code Type Description

FDA UNII

5CFY5Y69AM