THYROMEDAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H24I3NO4
Molecular Weight	735.133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCOC(=O)CC1=CC(I)=C(OC2=CC=C(OC)C(I)=C2)C(I)=C1

InChI

InChIKey=CNFICQVPDNZAHK-UHFFFAOYSA-N

InChI=1S/C21H24I3NO4/c1-4-25(5-2)8-9-28-20(26)12-14-10-17(23)21(18(24)11-14)29-15-6-7-19(27-3)16(22)13-15/h6-7,10-11,13H,4-5,8-9,12H2,1-3H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5939971 | https://www.ncbi.nlm.nih.gov/pubmed/14173582

Thyromedan is a thyroalkanoic acid derivative with hypocholesterolemic activity. In clinical trials, Thyromedan in daily doses of 8 to 32 mg caused a decrease in serum cholesterol levels. The serum total triglycerides and the α- and β-lipoprotein partition of cholesterol and triglycerides were unaffected.

Originator

Approval Year

PubMed

Title	Date	PubMed
THYROMIMETICS. I. THE SYNTHESIS AND HYPOCHOLESTEREMIC ACTIVITY OF SOME 3' AND 3',5'-ALKYL AND ARYL-3,5-DIIODOTHYRONINES.	1963 Sep	14173582
Serum lipids and glucose tolerance in diabetes during therapy with a thyromimetic agent.	1966 Jul-Aug	5939971

Patents

Sample Use Guides

In Vivo Use Guide

8 to 32 mg/day

Route of Administration: Oral

Name

Type

Language

THYROMEDAN

Common Name

English

TYROMEDAN

Official Name

English

BENZENEACETIC ACID, 3,5-DIIODO-4-(3-IODO-4-METHOXYPHENOXY)-, 2-(DIETHYLAMINO)ETHYL ESTER

Common Name

English

tyromedan [INN]

Common Name

English

2-(DIETHYLAMINO)ETHYL (3,5-DIIODO-4-(3-IODO-4-METHOXYPHENOXY)PHENYL)ACETATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1553