PROCINONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H34F2O7
Molecular Weight	508.5515
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]4(F)[C@@]2([H])C[C@H](F)C5=CC(=O)C=C[C@]45C

InChI

InChIKey=UBOIMZIXNXGQOH-RTWVSBIPSA-N

InChI=1S/C27H34F2O7/c1-6-22(33)34-13-20(32)27-21(35-23(2,3)36-27)11-15-16-10-18(28)17-9-14(30)7-8-24(17,4)26(16,29)19(31)12-25(15,27)5/h7-9,15-16,18-19,21,31H,6,10-13H2,1-5H3/t15-,16-,18-,19-,21+,24-,25-,26-,27+/m0/s1

HIDE SMILES / InChI

Description
Sources: http://www.drugfuture.com/mt/tetracosactide.pdf | https://www.ncbi.nlm.nih.gov/pubmed/752447 | https://www.ncbi.nlm.nih.gov/pubmed/6853627

Procinonide is a derivative of fluocinolone acetonide that has been applied topically with fluocinonide and ciprocinonide in the management of various skin disorders.

Originator

Approval Year

PubMed

Title	Date	PubMed
The use of mixtures of topical corticosteroids as a mechanism for improving total drug bioavailability: a preliminary report.	1978	752447

Patents

Name

Type

Language

PROCINONIDE

Official Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6,9-DIFLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-21-(1-OXOPROPOXY)-, (6.ALPHA.,11.BETA.,16.ALPHA)-

Common Name

English

6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-propionate

Common Name

English

PROCINONIDE [USAN]

Common Name

English

procinonide [INN]

Common Name

English

RS-2362

Code

English

PROCINONIDE [MART.]

Common Name

English

Procinonide [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521