U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Possibly Marketed Outside US
Source:
EnBrace HR by Jaymac Pharmaceuticals, Llc
Source URL:
First approved in 2011

Class (Stereo):
CHEMICAL (ACHIRAL)



Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).
Status:
Possibly Marketed Outside US
Source:
EnBrace HR by Jaymac Pharmaceuticals, Llc
Source URL:
First approved in 2011

Class (Stereo):
CHEMICAL (ACHIRAL)



Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).
Status:
Possibly Marketed Outside US
Source:
EnBrace HR by Jaymac Pharmaceuticals, Llc
Source URL:
First approved in 2011

Class (Stereo):
CHEMICAL (ACHIRAL)



Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).
Status:
Possibly Marketed Outside US
Source:
Canada:AMPROLIUM
Source URL:
First approved in 1990

Class (Stereo):
CHEMICAL (ACHIRAL)



Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.
Status:
Possibly Marketed Outside US
Source:
Canada:AMPROLIUM
Source URL:
First approved in 1990

Class (Stereo):
CHEMICAL (ACHIRAL)



Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.
Status:
Possibly Marketed Outside US
Source:
Canada:AMPROLIUM
Source URL:
First approved in 1990

Class (Stereo):
CHEMICAL (ACHIRAL)



Amprolium Hydrochloride is a broad spectrum, potent coccidiostat (anti-protozoal) used for the treatment and prevention of Coccidiosis in cattle, goats, sheep, and poultry (chicken and turkey) in veterinary. Amprolium probably acts by inhibiting thiamine uptake by parasites and thus creates disorders in the metabolism of parasites.
Status:
Possibly Marketed Outside US
Source:
Japan:Octotiamine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Octotiamine is an analogue of vitamin B1. As a component of vitamin complex used for the treatment of vitamin B1 deficiency; vitamin B1 supplement.
Status:
Possibly Marketed Outside US
Source:
Japan:Cetotiamine Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Dicethiamine hydrochloride (DCET) is a vitamin B(1) derivative that has excellent absorbability and transformability in tissues. It is an analogue of thiamine, improved performance in an animal model of complex fatigue.
Status:
Possibly Marketed Outside US
Source:
Japan:Thiamine Disulfide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Thiamine disulfide is a vitamin B1 derivative. It is used as a component of vitamin complexes for the treatment of neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies, for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, and ischialgia. It has being shown to be a potent inhibitor of human immunodeficiency virus (type-1) production, suggesting that thiamine disulfide may be important for AIDS chemotherapy.
Status:
Possibly Marketed Outside US
Source:
Japan:Cetotiamine Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Dicethiamine hydrochloride (DCET) is a vitamin B(1) derivative that has excellent absorbability and transformability in tissues. It is an analogue of thiamine, improved performance in an animal model of complex fatigue.