MONOPHOSPHOTHIAMINE PHOSPHATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H18N4O4PS.H2O4P
Molecular Weight	442.322
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MONOPHOSPHOTHIAMINE PHOSPHATE

Structure Search

SMILES

OP(O)([O-])=O.CC1=C(CCOP(O)(O)=O)SC=[N+]1CC2=CN=C(C)N=C2N

InChI

InChIKey=CUWOKLAYADTBBR-UHFFFAOYSA-N

InChI=1S/C12H17N4O4PS.H3O4P/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;1-5(2,3)4/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);(H3,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C12H18N4O4PS
Molecular Weight	345.334
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O4P
Molecular Weight	96.9872
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5151224 | https://www.ncbi.nlm.nih.gov/pubmed/5734623 | https://www.ncbi.nlm.nih.gov/pubmed/676062 | https://www.rlsnet.ru/tn_index_id_5374.htm

Monophosphothiamine is thiamine derivative used for the treatment of neuritis, polyneuritis, asthenic conditions (weakness), as an additional remedy for chronic blood circulation insufficiency, chronic gastritis accompanied by motor and secretory disorders functions of the stomach. Monophosphothiamine underwent metabolic phosphorylation to active metabolite thiamine pyrophosphate, that acts as a coenzyme in the different metabolic process.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Separation by ion exchange chromatography and spectrophotometric determination of cocarboxylase, monophosphothiamine and thiamine].	1971	5151224

Patents

Sample Use Guides

In Vivo Use Guide

0,01 - 0.03 g 3-4 times a day (after food) for 3-4 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:39:32 GMT 2025` Edited by `admin` on `Mon Mar 31 22:39:32 GMT 2025`
Record UNII	JS7TVM93UY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MONOPHOSPHOTHIAMINE PHOSPHATE

Common Name

English

THIAMINE PHOSPHORIC ACID ESTER PHOSPHATE

Preferred Name

English

Thiamine phosphoric acid ester phosphate [WHO-DD]

Common Name

English

THIAMINE PHOSPHORIC ACID ESTER PHOSPHATE SALT

Common Name

English

THIAMINE, HYDROXIDE, DIHYDROGEN PHOSPHATE (ESTER), INNER SALT, PHOSPHATE (1:1)

Common Name

English

THIAMINE PHOSPHATE (1:1) (SALT), DIHYDROGEN PHOSPHATE (ESTER)

Common Name

English

THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(2-(PHOSPHONOOXY)ETHYL)-, PHOSPHATE (1:1)

Systematic Name

English

UMBEON

Brand Name

English

Code System Code Type Description

FDA UNII

JS7TVM93UY