U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H17N4O7P2S.H.4H2O
Molecular Weight 496.368
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COCARBOXYLASE TETRAHYDRATE

SMILES

[H+].O.O.O.O.CC1=C(CCOP([O-])(=O)OP(O)([O-])=O)SC=[N+]1CC2=CN=C(C)N=C2N

InChI

InChIKey=KLOLNRGPRQYTIW-UHFFFAOYSA-N
InChI=1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2

HIDE SMILES / InChI
Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).

Originator

Curator's Comment: K. Lohmann and Ph. Schuster isolated in 1937 the coenzyme of the carboxylase from yeast in the form of the aneurin-pyrophosphoric acid-ester-chloride. The term cocarboxylase defines the inner salt of the aneurin-pyrophosphoric acid ester.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Branched-chain α-ketoacid dehydrogenase complex
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Cernevit

Approved Use

This formulation is indicated as a daily multivitamin maintenance dosage for adults and children aged 11 years and above receiving parenteral nutrition. It is also indicated in other situations where administration by the intravenous route is required. Such situations include surgery, extensive burns, fractures and other trauma, severe infectious diseases, and comatose states, which may provoke a “stress” situation with profound alterations in the body’s metabolic demands and consequent tissue depletion of nutrients. The physician should not await the development of clinical signs of vitamin deficiency before initiating vitamin therapy. This product (administered in intravenous fluids under proper dilution) contributes intake of these necessary vitamins, except Vitamin K, toward maintaining the body’s normal resistance and repair processes. Patients with multiple vitamin deficiencies or with markedly increased requirements may be given multiples of the daily dosage for two or more days as indicated by the clinical status.

Launch Date

1999
Preventing
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Thiamin diphosphate in biological chemistry: exploitation of diverse thiamin diphosphate-dependent enzymes for asymmetric chemoenzymatic synthesis.
2009 Jun
Thiamine and magnesium deficiencies: keys to disease.
2015 Feb
Ion pair liquid chromatography method for the determination of thiamine (vitamin B1) homeostasis.
2016 Jan
Patents

Sample Use Guides

In Vivo Use Guide
After no added thiamine, the diet was then supplemented with 50. 100 and 150 mg of thiamine-HCL respectively for each of three succeeding weeks.
Route of Administration: Oral
Mitochondria were isolated from normal lymphoblasts and were incubated for 15 minutes with various concentrations of radioactive ThDP (Cocarboxylase), ranging from 50 to 200 ug.
Name Type Language
COCARBOXYLASE TETRAHYDRATE
WHO-DD  
Common Name English
THIAMINE DIPHOSPHATE FREE ESTER TETRAHYDRATE
MI  
Common Name English
THIAMINE DIPHOSPHATE FREE ESTER TETRAHYDRATE [MI]
Common Name English
THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(4,6,6-TRIHYDROXY-4,6-DIOXIDO-3,5-DIOXA-4,6-DIPHOSPHAHEX-1-YL)-, INNER SALT, HYDRATE (1:4)
Systematic Name English
THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(4,6,6-TRIHYDROXY-4,6-DIOXIDO-3,5-DIOXA-4,6-DIPHOSPHAHEX-1-YL)-, INNER SALT, TETRAHYDRATE
Systematic Name English
THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(4,6,6-TRIHYDROXY-3,5-DIOXA-4,6-DIPHOSPHAHEX-1-YL)-, INNER SALT, P,P'-DIOXIDE, TETRAHYDRATE
Systematic Name English
Cocarboxylase tetrahydrate [WHO-DD]
Common Name English
Code System Code Type Description
EVMPD
SUB38872
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY
MERCK INDEX
m10718
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY Merck Index
SMS_ID
100000129420
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY
PUBCHEM
45358321
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY
CAS
68684-55-9
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY
FDA UNII
749XRF8JS6
Created by admin on Sat Dec 16 10:07:03 GMT 2023 , Edited by admin on Sat Dec 16 10:07:03 GMT 2023
PRIMARY