U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 41 - 50 of 66 results

SULFACLOZINE is a competitive antagonist of para-aminobenzoic acid (PABA), a precursor of folic acid, in protozoa and bacteria. It is indicated for treatment of coccidiosis in poultry due to infection with Eimeria species, fowl typhoid due to infection with Salmonella gallinarum and fowl cholera due to infection with Pasteurella multocida. Adverse reactions are liver damage, allergic reactions. In poultry undesirable effects, as inappetence, diarrhoea, growth depression, or haemorrhages after administration of sulfaclozine are rare. Prolong use may cause crystal urea.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfaperine is a long-acting sulfonamide antibiotic.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Sulfadicramide, a sulfonamide with anti-anti-infective properties, it was applied as a 15% ointment for superficial infections of the eye.
Status:
Possibly Marketed Outside US
Source:
Sulfabrom by English, J.P. et al.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfabromomethazine is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis and various bacterial infections. Single oral doses of the drug have been used to treat calf diphteria and pneumonia, metritis, foot root and septic mastitis in cattle with repeated dose 48 hors later sometimes required. Use of sulfabromomethazine during the last 3 months of pregnancy should be avoided. The compound is now rarely used.
Status:
Possibly Marketed Outside US
Source:
Japan:Sulfamethopyrazine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfalene (INN, USAN) or Sulfametopyrazine (BAN) is a long-acting sulfonamide antibiotic used for the treatment of chronic bronchitis, urinary tract infections, and malaria. Sulfametopyrazine, by virtue of a long half-life, achieves peak blood levels of 120 mkg/ml or more which fall to around 30-50 mkg/ml one week after a single oral dose of 2 g. Long-term administration of this drug in the treatment of leprosy for up to 3 years has been accomplished without serious unwanted effects
structurally diverse
Status:
US Previously Marketed
Source:
21 CFR 310.527(a) hair loss prevention jojoba oil
Source URL:

Class:
STRUCTURALLY DIVERSE

Status:
First approved in 1941
Source:
Sulamyd by Schering
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfacetamide is a synthetic sulfonamide antibiotic, which exerts its effect through inhibition of bacterial dihydrofolate synthetase, an enzyme responsible for the conversion of p-aminobenzoic acid into folic acid in bacterias. The topical formulation of the drug is prescribed for the treatment of acne vulgaris and the ophtalmic formulation is used in patients with eye infections.
Status:
Investigational
Source:
INN:sulfapyrazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Sulfazamet is a sulfanilamide derivative that exhibits antibacterial activity against Streptococci sepsis
Status:
US Previously Marketed
First approved in 1981

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfadoxine is an antimalarial agent which, together with pyrimethamine, composes an FDA-approved drug, Fansidar. Sulfadoxine acts by inhibiting dihydropteroate synthase; it crosses the blood-brain barrier and achieves 30% to 60% of the plasma concentration.
Status:
US Previously Marketed
First approved in 1966

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial, shows bacteriostatic effects against Gram positive and Gram negative bacteria in vivo. It is used as a leprostatic agent and in the treatment of urinary tract infections. Orally active. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.