SULFAPERIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N4O2S
Molecular Weight	264.304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CN=C(NS(=O)(=O)C2=CC=C(N)C=C2)N=C1

InChI

InChIKey=DZQVFHSCSRACSX-UHFFFAOYSA-N

InChI=1S/C11H12N4O2S/c1-8-6-13-11(14-7-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.karger.com/Article/Abstract/414205 | http://www.genome.jp/dbget-bin/www_bget?dr:D07240 | http://www.drugfuture.com/chemdata/Sulfaperine.html

Sulfaperine is a long-acting sulfonamide antibiotic.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial dihydropteroate synthase 44 Target ID: CHEMBL2364668 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D07240	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 234 Sources: https://www.karger.com/Article/Abstract/414205	Curative		Approved 8429	SULFAPERINE Approved Use Unknown Launch Date 1958

PubMed

Title	Date	PubMed
Synthesis of (+)-8-deoxyvernolepin and its 11,13-dihydroderivative. A novel reaction initiated by sulfene elimination leads to the 2-Oxa-cis-decalin skeleton.	2002 Aug 9	12153243
Preparation of alpha-sulfenyl enones by thermal fragmentation of beta-sulfenyl enol triflates.	2002 Mar 21	11893188
Amination and [2,3]-sigmatropic rearrangement of propargylic sulfides using a ketomalonate-derived oxaziridine: synthesis of N-allenylsulfenimides.	2003 Sep 21	14527143
Direct organocatalytic asymmetric alpha-sulfenylation of activated C-H bonds in lactones, lactams, and beta-dicarbonyl compounds.	2005 Sep 19	16035005
Catalytic enantio- and diastereoselective formation of beta-sultones: ring-strained precursors for enantioenriched beta-hydroxysulfonyl derivatives.	2007	17330913
Proteins protect lipid membranes from oxidation by thiyl radicals.	2007 Mar 15	17306209
Synthesis and insecticidal activities of novel N-sulfenyl-N'-tert-butyl-N,N'-diacylhydrazines. 1. N-alkoxysulfenate derivatives.	2007 Nov 14	17941694
Comparison of benzene, nitrobenzene, and dinitrobenzene 2-arylsulfenylpyrroles.	2007 Sep 14	17705533
Regioselective hydroxysulfenylation of alpha,beta-unsaturated imines: enhanced stability of an intermediate radical.	2008	18553331
Synthesis of 4'-substituted cordycepins via benzenesulfenylation at the 4'-position as a key step.	2009	19749279

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

SULFAPERIN

Official Name

English

BT-325

Code

English

Sulfaperin [WHO-DD]

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(5-METHYL-2-PYRIMIDINYL)-

Systematic Name

English

SULFAPERINE [MI]

Common Name

English

SULFANILAMIDE, N1-(5-METHYL-2-PYRIMIDINYL)-

Systematic Name

English

sulfaperin [INN]

Common Name

English

4-AMINO-N-(5-METHYL-2-PYRIMIDINYL)BENZENESULFONAMIDE

Systematic Name

English

SULFAPERIN [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J01ED06