SULFACLOZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9ClN4O2S
Molecular Weight	284.722
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=CC=C(C=C1)S(=O)(=O)NC2=NC(Cl)=CN=C2

InChI

InChIKey=QKLPUVXBJHRFQZ-UHFFFAOYSA-N

InChI=1S/C10H9ClN4O2S/c11-9-5-13-6-10(14-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

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Description
Sources: http://www.vetpac.co.za/product/detail/id/5
Curator's Comment: description was created based on several sources, including: http://en.kimiafaam.com/allp/p/coc/10.php | http://www.bela-pharm.com/nc/produkte/gefluegel.html?download=Sulfaclozin-Na_60_prozent-K068-1209.pdf

SULFACLOZINE is a competitive antagonist of para-aminobenzoic acid (PABA), a precursor of folic acid, in protozoa and bacteria. It is indicated for treatment of coccidiosis in poultry due to infection with Eimeria species, fowl typhoid due to infection with Salmonella gallinarum and fowl cholera due to infection with Pasteurella multocida. Adverse reactions are liver damage, allergic reactions. In poultry undesirable effects, as inappetence, diarrhoea, growth depression, or haemorrhages after administration of sulfaclozine are rare. Prolong use may cause crystal urea.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
para-aminobenzoic acid metabolic process 3 Target ID: GO:0046482 Sources: http://www.vetpac.co.za/product/detail/id/5	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Coccidiosis 45 Sources: http://www.vetpac.co.za/product/detail/id/5	Curative	Approved 8429	ESB3 Approved Use ESB 3 is indicated for treatment of coccidiosis in poultry due to infection with Eimeria species, fowl typhoid due to infection with Salmonella gallinarum and fowl cholera due to infection with Pasteurella multocida. It can be also used for coccidiosis treatment in Lambs, Calves and Rabbit.
Fowl typhoid 4 Sources: http://www.vetpac.co.za/product/detail/id/5	Curative	Approved 8429	ESB3 Approved Use ESB 3 is indicated for treatment of coccidiosis in poultry due to infection with Eimeria species, fowl typhoid due to infection with Salmonella gallinarum and fowl cholera due to infection with Pasteurella multocida. It can be also used for coccidiosis treatment in Lambs, Calves and Rabbit.
Fowl cholera 4 Sources: http://www.vetpac.co.za/product/detail/id/5	Curative	Approved 8429	ESB3 Approved Use ESB 3 is indicated for treatment of coccidiosis in poultry due to infection with Eimeria species, fowl typhoid due to infection with Salmonella gallinarum and fowl cholera due to infection with Pasteurella multocida. It can be also used for coccidiosis treatment in Lambs, Calves and Rabbit.

PubMed

Title	Date	PubMed
[Effectiveness of sulfachlorpyrazine in coccidiosis of rabbits].	1973 Apr	4805788
[Combination of anticoccidial drugs: experimental studies of the efficacy of the sulfachloropyrazine-diaveridine-ethopabate combination in the prevention of avian coccidiosis].	1974 Apr-Jun	4435681
Effect of sulfachloropyrazine in the drinking water of chickens infected experimentally with fowl cholera.	1974 Jul	4851697
[Action of sodium sulfachlorpyrazine (ESB3) on the endogenous development of Eimeria tenella in the experimental infestation of chickens].	1983	6659349

Patents

Sample Use Guides

In Vivo Use Guide

Poultry: Dissolve 1g Sulfaclozine (Sulfachloropyrazine) sodium monohydrate 30% per liter water. This provides approximately 50 mg active ingredient, or 170 mg Sulfaclozine (Sulfachloropyrazine) sodium monohydrate, per kg bodyweight. Treat for 3 consecutive days and repeat after a 2 days break if necessary (Shuttle programs like day 1, 3, 5, 7, 9 or 1, 2, 5, 6, 9 have also been found effective). · For coccidiosis in chicken caused by E. tenella and E. necatrix doses of 1.5g to 2.0g are indicated (75-100 g in 50 liters of drinking water). · For the treatment of cholera and typhoid, doses of 1 to 2 g Sulfaclozine (Sulfachloropyrazine) sodium monohydrate per liter water for at least 5 days are required. Sheep and Goats: 120 mg Sulfaclozine per kg body weight (Dissolve a full sachet in 1 liter drinking water and administer 12 ml for each 10kg Body weight).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

SULFACLOZINE

Official Name

English

SULFACHLOROPYRAZINE

Common Name

English

sulfaclozine [INN]

Common Name

English

SULFATYF

Common Name

English

N(SUP 1)-(6-CHLOROPYRAZINYL)SULFANILAMIDE

Systematic Name

English

N(SUP 1)-(1-(M-CHLOROPHENYL)-3-METHYL-5-PYRAZOLYL)SULFANILAMIDE

Systematic Name

English

ESB-3

Code

English

ESB3

Brand Name

English

SULFACLOZINE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QP51AG04