SULFAPERIN

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N4O2S
Molecular Weight	264.304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=CN=C(NS(=O)(=O)C2=CC=C(N)C=C2)N=C1

InChI

InChIKey=DZQVFHSCSRACSX-UHFFFAOYSA-N

InChI=1S/C11H12N4O2S/c1-8-6-13-11(14-7-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H12N4O2S
Molecular Weight	264.304
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Sulfaperine is a long-acting sulfonamide antibiotic.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial dihydropteroate synthase 44	Inhibitor 8,504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 235	Curative		Approved 8,583	SULFAPERINE

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2,252	inhibitor 2,438	inhibitor 2,507	inhibitor 2,217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2C19 2,057 CYP1A2 2,153

Drug as perpetrator

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Target	Modality	Activity
CYP1A2 2,333	inhibitor 4,027	no
CYP2C19 2,141	inhibitor 4,027	no
CYP2C9 2,497	inhibitor 4,027	no
CYP2D6 2,546	inhibitor 4,027	no
CYP3A4 2,633	inhibitor 4,027	no

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Tox targets

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Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2,263	inhibitor 2,237

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PubMed

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Title	Date	PubMed
Direct organocatalytic asymmetric alpha-sulfenylation of activated C-H bonds in lactones, lactams, and beta-dicarbonyl compounds.	2005 Sep 19	16035005
Catalytic enantio- and diastereoselective formation of beta-sultones: ring-strained precursors for enantioenriched beta-hydroxysulfonyl derivatives.	2007	17330913
Proteins protect lipid membranes from oxidation by thiyl radicals.	2007 Mar 15	17306209
Synthesis and insecticidal activities of novel N-sulfenyl-N'-tert-butyl-N,N'-diacylhydrazines. 1. N-alkoxysulfenate derivatives.	2007 Nov 14	17941694
Comparison of benzene, nitrobenzene, and dinitrobenzene 2-arylsulfenylpyrroles.	2007 Sep 14	17705533

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	W5E840UV9P
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

SULFAPERINE [MI]

Preferred Name

English

SULFAPERIN

Official Name

English

BT-325

Code

English

Sulfaperin [WHO-DD]

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(5-METHYL-2-PYRIMIDINYL)-

Systematic Name

English

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Classification Tree

Code System

Code

Long-acting sulfonamides

WHO-ATC

J01ED06

Anti-Infective Agent

NCI_THESAURUS

C29739

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Code System

Code

Type

Description

DRUG BANK

DB13320

PRIMARY

SMS_ID

100000083275

PRIMARY

PUBCHEM

68933

PRIMARY

FDA UNII

W5E840UV9P

PRIMARY

ChEMBL

CHEMBL2105499

PRIMARY

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Related Record

Type

Details


					W5E840UV9P

SULFAPERIN

ACTIVE MOIETY

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SMILES

InChI

Originator

Approval Year

Targets

Conditions

Overview

OverviewOther

Drug as perpetrator​

Tox targets

PubMed

Patents

Sample Use Guides

Drug as perpetrator