SULFABROMOMETHAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13BrN4O2S
Molecular Weight	357.226
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC(C)=C1Br

InChI

InChIKey=KWXCNODTHBHSIQ-UHFFFAOYSA-N

InChI=1S/C12H13BrN4O2S/c1-7-11(13)8(2)16-12(15-7)17-20(18,19)10-5-3-9(14)4-6-10/h3-6H,14H2,1-2H3,(H,15,16,17)

HIDE SMILES / InChI

Molecular Formula	C12H13BrN4O2S
Molecular Weight	357.226
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?type=all&dictionary=NCI%20Metathesaurus&code=C2825330&sab=FDA | https://books.google.ru/books?id=ievLulSqwBAC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Sulfabromomethazine is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis and various bacterial infections. Single oral doses of the drug have been used to treat calf diphteria and pneumonia, metritis, foot root and septic mastitis in cattle with repeated dose 48 hors later sometimes required. Use of sulfabromomethazine during the last 3 months of pregnancy should be avoided. The compound is now rarely used.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
T. gondii dihydropteroate synthase (Q2HWT3_TOXGO) 3 Target ID: T. gondii dihydropteroate synthase (Q2HWT3_TOXGO) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8851601	Inhibitor 8297		230.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.trademarkia.com/sulfabrom-72059044.html https://www.drugs.com/international/sulfabromomethazine.html	Curative		Approved 8429	Sulfabrom Approved Use Used in the poultry, swine and cattle industries for the treatment of coccidiosis and various bacterial infections. Launch Date 1958
Bacterial infections 234 Sources: http://www.trademarkia.com/sulfabrom-72059044.html https://www.drugs.com/international/sulfabromomethazine.html	Curative		Approved 8429	Sulfabrom Approved Use Used in the poultry, swine and cattle industries for the treatment of coccidiosis and various bacterial infections. Launch Date 1958

PubMed

Title	Date	PubMed
The pharmacology of sulfabromomethazine, a new long-acting sulfonamide, in cattle.	1958 Apr	13533757
Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.	1996 Mar	8851601

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:08:41 GMT 2023` Edited by `admin` on `Fri Dec 15 15:08:41 GMT 2023`
Record UNII	PQK2N461KJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFABROMOMETHAZINE

Common Name

English

N(SUP 1)-(5-BROMO-4,6-DIMETHYL-2-PYRIMIDINYL)SULFANILAMIDE

Systematic Name

English

SULFABROMOMETHAZINE [MI]

Common Name

English

NSC-5874

Code

English

Classification Tree Code System Code

CFR

21 CFR 520.2170