U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 381 - 390 of 553 results

Status:
Possibly Marketed Outside US
Source:
Canada:BARIUM CARBONATE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Barium hydroxide, Ba(OH)2, is also known as baryta. Barium hydroxide crystallizes as the octahydrate, which can be converted to the monohydrate by heating in air. The anhydrous hydroxide has only a secondary industrial importance; the monohydrate and octahydrate are used in industry on a far larger scale. Barium hydroxide, especially the monohydrate, is used to produce organic barium compounds such as additives for oil and stabilizers for plastics. In addition, barium hydroxide is used for dehydration and deacidification, especially for removing sulfuric acid from fats, oils, waxes, and glycerol.
Status:
Possibly Marketed Outside US
Source:
NCT00442962: Phase 4 Interventional Completed HIV Infections
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Maleic acid monosodium salt. Used in water soluble polymers preparation.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Acetyltryptophan,DL- functions readily as a component of the food in place of the free amino acid - a greater amount of acetyltryptophane,DL- than dl-tryptophane may be available to man. Acetyltryptophan,DL- is used as an additive in the protein microbubbles, used in various biomedical applications such as contrast imaging, targeted drug and gene delivery, delivery of drugs through blood brain barrier (BBB) and IV O2 delivery etc. In the breast cancer biomarkers search, lower levels of endogenous metabolite Acetyltryptophan, DL- was identified in the fluid from the affected breasts compared to the control breast fluid.
Status:
Possibly Marketed Outside US
Source:
Canada:SKATOLUM
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Skatole or 3-methylindole is a mildly toxic white crystalline organic compound belonging to the indole family. It is formed in the intestine by the bacterial decomposition of l-tryptophan and found in fecal matter, to which it imparts its characteristic odor. Skatole is a partial AhR agonist. Skatole is used in perfume compositions and in artificial Civet bases.
Status:
Possibly Marketed Outside US
Source:
Canada:CLOROPHENE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Chlorophene is a halogenated phenolic compound that functions as a biocide and preservative in cosmetics. In Europe, the maximum authorized concentration allowed for Chlorophene is 0.2%. The glucuronic acid conjugate, the sulfate ester conjugate, and two other minor metabolites of Chlorophene were profiled in rat urine during pharmacokinetic tests. Chlorophene is incompletely absorbed through rat skin. In several anumal species these chemicals exhibited low oral toxicity. Some evidence of toxicity was found in short-term oral toxicity studies in mice and rats with nephropathy as the principal finding. Rats and mice dosed with Chlorophene for 2 years had a dose-related and sex-related increase in the severity of nephropathy. In another set of animal tests Chlorophene was found to be an ocular irritant. There was no readily available inhalation profile for Chlorophene. Chlorophene was severely irritating to rabbits in most dermal irritation studies. Chlorophene was found to be mutagenic in four in-vitro mammalian test systems. However, neoplasms were not observed in rats treated with Chlorophene for 2 years but, in mice treated similarly a significant incidence of neoplasms was observed. A 1-year National Toxicology Program (NTP) study concluded that Chlorophene was a cutaneous irritant and a weak skin tumor promoter but had no activity as an initiator or complete carcinogen. Some reactions to Chlorophene occurred in some, but not all, clinical dermal sensitization tests.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Acedoben (4-acetamidobenzoic acid) is a benzoic acid derivative and a metabolite of benzocaine. It is a component of immunomodulatory drug inosine pranobex, which is used to treat mucocutaneous infections due to herpes simplex virus (type 1 and/or type II), genital warts as adjunctive therapy to podophyllin or carbon dioxide laser, and subacute sclerosing panencephalitis.
Status:
Possibly Marketed Outside US
Source:
Javlor by Fabre, P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Vinflunine (Javlor) is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine, at the lowest effective concentrations, interacts with the Vinca alkaloid binding site on tubulin, suppresses microtubule dynamics (switching at microtubule ends between phases of slow growth and rapid shortening) and microtubule treadmilling (growth at the plus end and shortening at the minus end of the microtubule), causes cell cycle arrest which appears on fluorescence-activated cell sorting analysis as a G2 + M phase arrest, and is associated with an accumulation of cells in mitosis leading to cell death via apoptosis. Vinflunine has been been approved for advanced or metastatic transitional cell carcinoma of the urothelial tract. Pierre Fabre submitted an extension to the EU authorisation to add treatment of advanced breast cancer.
Status:
Possibly Marketed Outside US
Source:
Vinglycinate by ZYF Pharm Chemical
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Vinglycinate is a derivative of anticancer drug vinblastine. Vinglycinate was first synthesized in the 1960s and was demonstrated to be a safer alternative to other vinca alkaloids while maintaining comparable activity for the treatment of leukemia in vivo. In clinical trials, administration of vinglycinate resulted in a beneficial response in Hodgkin's disease, lymphosarcoma, bronchogenic carcinoma, and chondrosarcoma. However, to achieve response rates similar to vinblastine, 10-fold higher dose was required, thus making treatment economically unfeasible.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Butedronic acid is used for diagnostic purposes. Tetrasodium salt of butedronic acid is bone imaging agent.
Status:
Possibly Marketed Outside US
Source:
Operidine by Janssen Pharmaceutica
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

PHENOPERIDINE is an opioid analgesic partly metabolized to meperidine in the liver. It is derived from pethidine by replacing the N methyl by a phenyl propanol chain. It is reputed to be a typical morphine-like analgesic characterized by its high potency, rapid onset of action, the intensity of its peak effect and the short duration of its pharmacological effects. It is used in general anesthesia.

Showing 381 - 390 of 553 results