BUTEDRONIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H10O10P2
Molecular Weight	292.0744
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC(C(P(O)(O)=O)P(O)(O)=O)C(O)=O

InChI

InChIKey=LDTZSTJLVYBEKB-UHFFFAOYSA-N

InChI=1S/C5H10O10P2/c6-3(7)1-2(4(8)9)5(16(10,11)12)17(13,14)15/h2,5H,1H2,(H,6,7)(H,8,9)(H2,10,11,12)(H2,13,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/butedronic-acid.html | DOI: 10.1038/clpt.1988.41 | (2013) Pharmeceutical manufacturing encyclopedia, page 753, retrieved from: https://books.google.ru/books?id=_J2ti4EkYpkC

Butedronic acid is used for diagnostic purposes. Tetrasodium salt of butedronic acid is bone imaging agent.

Approval Year

PubMed

Title	Date	PubMed
Bone infarction resulting from parosteal soft tissue angiosarcoma.	2002 Jan	11805489
Skeletal scintigraphy in acquired adult Fanconi syndrome.	2002 Jan	11805488
Monostotic Paget's Disease of a cervical vertebra: differential diagnosis with F-18 FDG positron emission tomography using a coincidence technique and with Tc-99m dicarboxypropane diphosphonate.	2002 Jul	12072790
99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy.	2002 Mar	12002714
Bone pain with scintigraphy suggestive of widespread metastases--do not forget phosphate.	2002 Mar	11865102
Bone scintigraphy using Tc-99m DPD and F18-FDG in a patient with SAPHO syndrome.	2003	12635949
[Stress fracture of the sacrum in a professional basketball athlete].	2003 Apr	12677517
Unusual bilateral Tc-99m DPD uptake on bone scan.	2003 Nov	14578714
Chemical and biological evaluation of technetium (I) tricarbonyl complexes with EHIDA and DPD. 99m (I) complexes of EHIDA and DPD.	2004	15318303
Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.	2004 Apr	15097810
Assessment of aseptic loosening of the acetabular component in a total hip replacement with 99mTc-DPD-SPECT/spiral-CT hybrid imaging.	2005	16408361
Whole body bone scintigraphy after parachute accident.	2005 Feb	15847191
Alteration of the organ uptake of the (99m)Tc-radiopharmaceuticals, (99m)Tc-DPD, (99m)Tc-DMSA, (99m)Tc-tin colloid and (99m)Tc-MAA, induced by the applied cytotoxic drugs methotrexate sodium and cyclophosphamide.	2005 May	15838423
Puzzling intestinal uptake in 99mTc-DPD bone scintigraphy.	2006	16969952
Gastric accumulation of bone seeking agent in a patient with advanced gastric cancer.	2007 Feb	17297271
Bone scintigraphy as a prognostic indicator for bone collapse in the early phases of femoral head osteonecrosis.	2007 Jun	17561588
[Transient osteoporosis of the hip in pregnancy. Successful treatment with calcitonin: a case report].	2007 Oct	17849129
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc-DPD complex.	2008 Apr 15	18331797
[Diagnosis of senile cardiac amyloidosis by (99m)Tc-DPD scintigraphy].	2009 Apr	18922670
[Nuclear medical imaging in case of painful knee arthroplasty].	2009 Jan	18597065
The assessment of bee venom responses in an experimental model of mono-arthritis using Tc-99m DPD bone scintigraphy.	2010 Jul	20379856

Name

Type

Language

BUTEDRONIC ACID

Official Name

English

BUTEDRONIC ACID, (±)-

Common Name

English

(DIPHOSPHONOMETHYL)SUCCINIC ACID

Systematic Name

English

BUTEDRONIC ACID [MI]

Common Name

English

3,3-diphosphono-1,2-propanedicarbonic acid [WHO-DD]

Common Name

English

2-(DIPHOSPHONOMETHYL)SUCCINIC ACID

Systematic Name

English

butedronic acid [INN]

Common Name

English

(±)-BUTEDRONIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67439