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Details

Stereochemistry RACEMIC
Molecular Formula C23H29NO3
Molecular Weight 367.4813
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENOPERIDINE

SMILES

CCOC(=O)C1(CCN(CCC(O)C2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=IPOPQVVNCFQFRK-UHFFFAOYSA-N
InChI=1S/C23H29NO3/c1-2-27-22(26)23(20-11-7-4-8-12-20)14-17-24(18-15-23)16-13-21(25)19-9-5-3-6-10-19/h3-12,21,25H,2,13-18H2,1H3

HIDE SMILES / InChI

Molecular Formula C23H29NO3
Molecular Weight 367.4813
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

PHENOPERIDINE is an opioid analgesic partly metabolized to meperidine in the liver. It is derived from pethidine by replacing the N methyl by a phenyl propanol chain. It is reputed to be a typical morphine-like analgesic characterized by its high potency, rapid onset of action, the intensity of its peak effect and the short duration of its pharmacological effects. It is used in general anesthesia.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Operidine

AUC

ValueDoseCo-administeredAnalytePopulation
1330 ng × min/mL
2 mg single, intravenous
PHENOPERIDINE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
193 min
2 mg single, intravenous
PHENOPERIDINE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
21.17%
15 μg/kg bw single, intravenous
PHENOPERIDINE plasma
Homo sapiens

Doses

PubMed

Patents

Substance Class Chemical
Record UNII
G9BH09J4JW
Record Status Validated (UNII)
Record Version