PHENOPERIDINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H29NO3
Molecular Weight	367.4813
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1(CCN(CCC(O)C2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=IPOPQVVNCFQFRK-UHFFFAOYSA-N

InChI=1S/C23H29NO3/c1-2-27-22(26)23(20-11-7-4-8-12-20)14-17-24(18-15-23)16-13-21(25)19-9-5-3-6-10-19/h3-12,21,25H,2,13-18H2,1H3

HIDE SMILES / InChI

Molecular Formula	C23H29NO3
Molecular Weight	367.4813
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19186209 | https://www.ncbi.nlm.nih.gov/mesh/68010638 | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2044.1963.tb13699.x

PHENOPERIDINE is an opioid analgesic partly metabolized to meperidine in the liver. It is derived from pethidine by replacing the N methyl by a phenyl propanol chain. It is reputed to be a typical morphine-like analgesic characterized by its high potency, rapid onset of action, the intensity of its peak effect and the short duration of its pharmacological effects. It is used in general anesthesia.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://books.google.ru/books?id=o-bzCAAAQBAJ&pg=PA394&lpg=PA394&dq=Operidine retrieved from A Concise Encyclopaedia of Psychiatry: D. Leigh, C.M. Pare, J. Marks, p.394 https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=1308.11	Primary		Approved 8429	Operidine Approved Use A narcotic analgesic

PubMed

Title	Date	PubMed
Motor neuropathy associated with cimetidine.	1980 Oct 11	7427548
Contemporary strategies to preserve renal function during cardiac and vascular surgery.	2003	12556734
The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice.	2009 Apr 29	19186209

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:50:45 GMT 2023` Edited by `admin` on `Sat Dec 16 16:50:45 GMT 2023`
Record UNII	G9BH09J4JW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENOPERIDINE

Official Name

English

phenoperidine [INN]

Common Name

English

DL-PHENOPERIDINE

Common Name

English

R 1406

Code

English

IDS-NP-010

Code

English

ISONIPECOTIC ACID, 1-(3-HYDROXY-3-PHENYLPROPYL)-4-PHENYL-, ETHYL ESTER

Systematic Name

English

FENOPERIDINA

Common Name

English

PHENOPERIDINE [MI]

Common Name

English

NIH 7591

Code

English

Phenoperidine [WHO-DD]

Common Name

English

FENOPERIDINE

Common Name

English

NIH-7591

Code

English

R-1406

Code

English

1-(3-HYDROXY-3-PHENYLPROPYL)-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

N01AH04