BUTEDRONIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H10O10P2
Molecular Weight	292.0744
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC(C(P(O)(O)=O)P(O)(O)=O)C(O)=O

InChI

InChIKey=LDTZSTJLVYBEKB-UHFFFAOYSA-N

InChI=1S/C5H10O10P2/c6-3(7)1-2(4(8)9)5(16(10,11)12)17(13,14)15/h2,5H,1H2,(H,6,7)(H,8,9)(H2,10,11,12)(H2,13,14,15)

HIDE SMILES / InChI

Molecular Formula	C5H10O10P2
Molecular Weight	292.0744
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugfuture.com/chemdata/butedronic-acid.html | DOI: 10.1038/clpt.1988.41 | (2013) Pharmeceutical manufacturing encyclopedia, page 753, retrieved from: https://books.google.ru/books?id=_J2ti4EkYpkC

Butedronic acid is used for diagnostic purposes. Tetrasodium salt of butedronic acid is bone imaging agent.

Approval Year

PubMed

Title	Date	PubMed
Bone infarction resulting from parosteal soft tissue angiosarcoma.	2002 Jan	11805489
Skeletal scintigraphy in acquired adult Fanconi syndrome.	2002 Jan	11805488
Unusual bilateral Tc-99m DPD uptake on bone scan.	2003 Nov	14578714
Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.	2004 Apr	15097810
Tc-99m DPD uptake in the thigh from metastasis of adenocarcinoma of the rectum.	2005 Jan	15604976
Comparison of the effect of 99mTc-DPD and 99mTc-MDP on experimentally-induced osteoarthritis in the stifle joint of the dog.	2005 Jul-Aug	15999549
Alteration of the organ uptake of the (99m)Tc-radiopharmaceuticals, (99m)Tc-DPD, (99m)Tc-DMSA, (99m)Tc-tin colloid and (99m)Tc-MAA, induced by the applied cytotoxic drugs methotrexate sodium and cyclophosphamide.	2005 May	15838423
Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy.	2005 Sep 20	16168294
Puzzling intestinal uptake in 99mTc-DPD bone scintigraphy.	2006	16969952
Gastric accumulation of bone seeking agent in a patient with advanced gastric cancer.	2007 Feb	17297271
[Transient osteoporosis of the hip in pregnancy. Successful treatment with calcitonin: a case report].	2007 Oct	17849129
Labeling, characterization, and in vivo localization of a new 90Y-based phosphonate chelate 2,3-dicarboxypropane-1,1-diphosphonic acid for the treatment of bone metastases: Comparison with 99mTc-DPD complex.	2008 Apr 15	18331797
[Detection of bone metastasis of prostate cancer - comparison of whole-body MRI and bone scintigraphy].	2008 Aug	18512192
[Diagnosis of senile cardiac amyloidosis by (99m)Tc-DPD scintigraphy].	2009 Apr	18922670
[Nuclear medical imaging in case of painful knee arthroplasty].	2009 Jan	18597065
The assessment of bee venom responses in an experimental model of mono-arthritis using Tc-99m DPD bone scintigraphy.	2010 Jul	20379856

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:53:45 GMT 2023` Edited by `admin` on `Sat Dec 16 16:53:45 GMT 2023`
Record UNII	26PB1U68YF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTEDRONIC ACID

Official Name

English

BUTEDRONIC ACID, (±)-

Common Name

English

(DIPHOSPHONOMETHYL)SUCCINIC ACID

Systematic Name

English

BUTEDRONIC ACID [MI]

Common Name

English

3,3-diphosphono-1,2-propanedicarbonic acid [WHO-DD]

Common Name

English

2-(DIPHOSPHONOMETHYL)SUCCINIC ACID

Systematic Name

English

butedronic acid [INN]

Common Name

English

(±)-BUTEDRONIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67439