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Search results for lactic root_codes_comments in Code Comments (approximate match)
Status:
Possibly Marketed Outside US
Source:
21 CFR 333A
(2020)
Source URL:
First approved in 2020
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Fulvic acid is primarily studied for its effects on plants and soil. Fulvic acid is an organic and natural electrolyte. Depending on the situation, Fulvic acid can act as an electron donor or acceptor and an oxidizer or reducer. Fulvic acid has exhibited the ability to enhance the availability and adsorption of nutrients as well as prolong their time of residence. In the chick animal model Fulvic acid disturbed the processing of procollagen II in articular cartilage. Fulvic acid has being shown to attenuate homocysteine-induced cyclooxygenase-2 expression in human monocytes. Fulvic acid, the main active principle of Shilajit (a natural substance found mainly in the Himalayas), blocks tau self-aggregation, opening an avenue toward the study of Alzheimer's therapy. People take fulvic acid by mouth for brain disorders such as Alzheimer’s disease, as well as respiratory tract infections, cancer, fatigue, heavy metal toxicity, and preventing a condition in which the body tissues do not receive enough oxygen (hypoxia).
Status:
Possibly Marketed Outside US
Source:
JIKIMI Phytoncide by MY Corp.,Ltd
(2020)
Source URL:
First approved in 2020
Source:
JIKIMI Phytoncide by MY Corp.,Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
First approved in 2020
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Butyric acid (butanoic acid) belongs to a group of short-chain fatty acids and is thought to play several beneficial roles in the gastrointestinal tract. The butyric anion is easily absorbed by enteric cells and used as a main source of energy. Moreover, butyric acid is an important regulator of colonocyte proliferation and apoptosis, gastrointestinal tract motility and bacterial microflora composition in addition to its involvement in many other processes including immunoregulation and anti-inflammatory activity. Butyric acid shows a protective effect in inflammatory
response secondary to inflammatory bowel diseases. A beneficial effect of butyric acid as one constituent
of a multifaceted mechanism modulating gastrointestinal
function has also been stressed in patients with the stoma
and coexisting constipation. Butyric acid supplementation
combined with the use of probiotics should be adopted
as one of the basic therapeutic strategies in this
patient group, preceding treatment with laxatives. Sodium butyrate in the form of enemas (combined
in a mixture with A-300 silicon dioxide) may be a successful
method of therapeutic management in patients
with radiation proctitis. Sodium butyrate may also prevent diarrhea
through an increased passive absorption of water in the
colon and its effects on the gut microflora.
Status:
Possibly Marketed Outside US
First approved in 2019
Source:
M020
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Aminomethylbenzoic acid (or p-aminomethylbenzoic acid, or PAMBA) an antifibrinolytic agent. This drug has been used for the treatment of internal hemorrhage during chronic disseminated intravascular coagulation.
Status:
Possibly Marketed Outside US
Source:
NCT02819505: Phase 4 Interventional Completed Muscle Function
(2014)
Source URL:
First approved in 2019
Source:
M017
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Beta-alanine is an endogenous agonist of glycine receptor, which is used a supplementation among competitive athletes participating in a range of different sports. Beta-alanine has been shown to enhance muscular endurance and its supplementation appears to be most effective for exercise tasks that rely heavily on ATP synthesis from anaerobic glycolysis.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2019)
Source URL:
First approved in 2019
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Retinal, All-trans is one of the forms of vitamin A. It is an isomer of 11-cis-retinal, transductor of light into the neural signals. Retinal, All-trans is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinal, All-trans is associated with one of the two isoforms of cellular retinol-binding proteins (CRBP-I and CRBP-II). These proteins play important roles in retinoid biology and regulation of the metabolism of retinol and retinal.
Status:
Possibly Marketed Outside US
First approved in 2019
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Orotic acid is a minor dietary constituent. Historically it was believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin and is synthesized in the body, where it arises as an intermediate in the pathway for the synthesis of pyrimidine nucleotides. Orotic acid is converted to UMP by UMP synthase, a multifunctional protein with both orotate phosphoribosyl transferase and orotidylate decarboxylase activity. The most frequently observed inborn error of pyrimidine nucleotide synthesis is a mutation of the multifunctional protein UMP synthase. As a result, plasma orotic acid accumulates to high concentrations, and increased quantities appear in the urine. Orotic acid levels are elevated in the urea cycle defects ornithine transcarbamylase (OTC) deficiency, citrullinemia and argininosuccinic acidemia, as well as the mitochondrial transport disorder hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. Orotic acid is also elevated in hereditary orotic aciduria, or uridine monophosphate synthase deficiency, an autosomal recessive disorder characterized by megaloblastic anemia and crystalluria. In addition, orotic acid in combination with leflunomide is in the phase II of clinical trial to evaluate the clinical efficacy and safety of a combination in kidney transplant patients with high levels of Polyoma BK viruria for the purpose of preventing polyoma BK viremia and nephropathy, that could lead to kidney transplant loss from viral damage, acute rejection or both.
Status:
Possibly Marketed Outside US
First approved in 2018
Source:
21 CFR 343
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ethenzamide is an anti-inflammatory agent that was used for the treatment of common cold in Japan (in combinations with other NSAIDs).
Status:
Possibly Marketed Outside US
Source:
21 CFR 358H
(2018)
Source URL:
First approved in 2018
Source:
21 CFR 358H
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Shikimic acid (SA), an active metabolite of polyphenol-rich food intake, originally extracted from Illicium verum Hook. fil. is an indispensable starting material for the synthesis of the antiviral drug oseltamivir and others useful compounds. In the biological studies, SA has been reported to have anti-inflammatory, analgesia, antioxidant, antithrombotic, and antibacterial activities. SA can play an important role in reducing platelet activation, aggregation related thrombus formation and biomarkers of thrombogenesis in sedentary individuals. In addition, was investigated antibacterial activity of SA against S. aureus, which could be caused by the interactions of SA with S. aureus membrane proteins and lipids, resulting in causing cell membrane dysfunction and bacterial damage or even death.
Status:
Possibly Marketed Outside US
First approved in 2018
Source:
Peraflu D by minam medical
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Peracetic acid, also known as peroxyacetic acid, is an organic peroxide used an an antimicrobial agent. It is commonly utlized as a medical instrument and food industry disinfectant. Peracetic acid is also used in epoxidation of various alkenes, converting carbon–carbon double bonds into oxiranes. It is a strong oxidizing agent that can cause irritation to skin and respiratory tract.