ETHENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11NO2
Molecular Weight	165.1891
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=C(C=CC=C1)C(N)=O

InChI

InChIKey=SBNKFTQSBPKMBZ-UHFFFAOYSA-N

InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)

HIDE SMILES / InChI

Molecular Formula	C9H11NO2
Molecular Weight	165.1891
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.med.or.jp/english/pdf/2001_08/364_368.pdf

Ethenzamide is an anti-inflammatory agent that was used for the treatment of common cold in Japan (in combinations with other NSAIDs).

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Common cold 58 Sources: http://www.med.or.jp/english/pdf/2001_08/364_368.pdf	Primary		Approved 8429	NARON ACE Approved Use Unknown

PubMed

Title	Date	PubMed
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.	1999 Jan 8	10077225
Determination of plasma bromvalerylurea and its main metabolite by a simple high-performance liquid chromatographic method and quantitation of bromide by energy dispersive X-ray spectrometry in carbon tetrachloride-intoxicated rats.	2001 Aug 15	11499491
Preparation and clinical application of 2% diflunisal oral ointment for painful lesions of the oral mucosa.	2001 Nov	11725552
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.	2002 May	11977112
In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method.	2004 Mar	15018980
Grinding-induced equimolar complex formation between thiourea and ethenzamide.	2004 May	15133201
Salicylic acid-induced inactivation of creatine kinase in the presence of lactoperoxidase and H2O2.	2005 Jan 15	15698578
Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography.	2005 Mar 9	15740912
Influences of drugs on the oxygen uptake rate and biosorption of activated sludge.	2006 Jan	16394537
Continuous grinding kinetics of ethenzamide particles by fluidized-bed jet-milling.	2006 Mar	16556539
Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling.	2006 Mar 27	16427749
Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose.	2006 Mar 9	16434157
One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier.	2007 Jul 31	17582644
Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage.	2008 Sep 1	18800500
Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination.	2009 Jan 15	19146691
Distribution of ethenzamide and other ingredients on granule surfaces studied by Raman microspectroscopy and mapping.	2009 May	19530442
Herringbone array of hydrogen-bonded ribbons in 2-ethoxybenzamide from high-resolution X-ray powder diffraction.	2009 Nov	19893241
Photodegradation of pharmaceuticals and personal care products during UV and UV/H2O2 treatments.	2009 Oct	19712957
Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method.	2010 Apr	22247849
Ethenzamide-gentisic acid-acetic acid (2/1/1).	2010 Apr 10	21579106
(13)C Solid-state NMR chromatography by magic angle spinning (1)H T(1) relaxation ordered spectroscopy.	2010 Feb	19900827
Development of theophylline floating microballoons using cellulose acetate butyrate and/or Eudragit RL 100 polymers with different permeability characteristics.	2010 Jan	21589766
Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method.	2010 Jul	22247865

Patents

Sample Use Guides

In Vivo Use Guide

2 pills containing 84 mg of ethenzamide 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:51:05 UTC 2023` Edited by `admin` on `Sat Dec 16 04:51:05 UTC 2023`
Record UNII	L929ZCK4BF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ETHENZAMIDE

Official Name

English

Ethenzamide [WHO-DD]

Common Name

English

ETHENZAMIDE [MI]

Common Name

English

ETHENZAMIDE [JAN]

Common Name

English

O-ETHOXYBENZAMIDE

Common Name

English

ETENZAMIDE

Common Name

English

NSC-28787

Code

English

ethenzamide [INN]

Common Name

English

ETHOXYBENZAMIDE

Systematic Name

English

ETHENZAMIDE [MART.]

Common Name

English

J3.352I

Code

English

Classification Tree Code System Code

WHO-ATC

N02BA77