ETHENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11NO2
Molecular Weight	165.1891
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCOC1=C(C=CC=C1)C(N)=O

InChI

InChIKey=SBNKFTQSBPKMBZ-UHFFFAOYSA-N

InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)

HIDE SMILES / InChI

Molecular Formula	C9H11NO2
Molecular Weight	165.1891
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Ethenzamide is an anti-inflammatory agent that was used for the treatment of common cold in Japan (in combinations with other NSAIDs).

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Common cold	Primary		Approved	NARON ACE

F_unbound

F_unbound

Value	Dose	Co-administered	Analyte	Population
100%			ETHENZAMIDE unknown	Homo sapiens

Doses

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Dose	Population	Adverse events
500 mg single, oral Studied dose	unhealthy	Other AEs: Eruption...

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AEs

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AE	Significance	Dose	Population
Eruption	1 pt	500 mg single, oral Studied dose	unhealthy

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PubMed

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Title	Date	PubMed
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.	1999 Jan 8	10077225
Determination of plasma bromvalerylurea and its main metabolite by a simple high-performance liquid chromatographic method and quantitation of bromide by energy dispersive X-ray spectrometry in carbon tetrachloride-intoxicated rats.	2001 Aug 15	11499491
Preparation and clinical application of 2% diflunisal oral ointment for painful lesions of the oral mucosa.	2001 Nov	11725552
Preparation of solid dispersion for ethenzamide-carbopol and theophylline-carbopol systems using a twin screw extruder.	2002 Jun	12045335
In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method.	2004 Mar	15018980

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Patents

Sample Use Guides

In Vivo Use Guide

2 pills containing 84 mg of ethenzamide 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	L929ZCK4BF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETHENZAMIDE

Official Name

English

Ethenzamide [WHO-DD]

Common Name

English

ETHENZAMIDE [MI]

Common Name

English

ETHENZAMIDE [JAN]

Common Name

English

O-ETHOXYBENZAMIDE

Common Name

English

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Classification Tree

Code System

Code

Salicylic acid and derivatives

WHO-ATC

N02BA77

Analgesic and Antipyretic

NCI_THESAURUS

C257

Salicylic acid and derivatives

WHO-VATC

QN02BA57

Salicylic acid and derivatives

WHO-VATC

QN02BA07

Salicylic acid and derivatives

WHO-ATC

N02BA07

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Code System

Code

Type

Description

ECHA (EC/EINECS)

213-346-4

PRIMARY

SMS_ID

100000082616

PRIMARY

ChEMBL

CHEMBL1483877

PRIMARY

EVMPD

SUB07274MIG

PRIMARY

FDA UNII

L929ZCK4BF

PRIMARY

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Related Record

Type

Details


					L929ZCK4BF

ETHENZAMIDE

ACTIVE MOIETY

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SMILES

InChI

Originator

Approval Year

Conditions

Funbound

Doses

AEs

PubMed

Patents

Sample Use Guides

F_unbound