FULVIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H12O8
Molecular Weight	308.2403
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(O)CC2=C(CO1)C(=O)C3=C(O2)C=C(O)C(O)=C3C(O)=O

InChI

InChIKey=FCYKAQOGGFGCMD-UHFFFAOYSA-N

InChI=1S/C14H12O8/c1-14(20)3-8-5(4-21-14)11(16)9-7(22-8)2-6(15)12(17)10(9)13(18)19/h2,15,17,20H,3-4H2,1H3,(H,18,19)

HIDE SMILES / InChI

Molecular Formula	C14H12O8
Molecular Weight	308.2403
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.webmd.com/vitamins-supplements/ingredientmono-1320-fulvic%20acid.aspx?activeingredientid=1320&activeingredientname=fulvic%20acid | https://www.ncbi.nlm.nih.gov/pubmed/1662604 | https://www.ncbi.nlm.nih.gov/pubmed/25888188 | https://www.ncbi.nlm.nih.gov/pubmed/22482077

Fulvic acid is primarily studied for its effects on plants and soil. Fulvic acid is an organic and natural electrolyte. Depending on the situation, Fulvic acid can act as an electron donor or acceptor and an oxidizer or reducer. Fulvic acid has exhibited the ability to enhance the availability and adsorption of nutrients as well as prolong their time of residence. In the chick animal model Fulvic acid disturbed the processing of procollagen II in articular cartilage. Fulvic acid has being shown to attenuate homocysteine-induced cyclooxygenase-2 expression in human monocytes. Fulvic acid, the main active principle of Shilajit (a natural substance found mainly in the Himalayas), blocks tau self-aggregation, opening an avenue toward the study of Alzheimer's therapy. People take fulvic acid by mouth for brain disorders such as Alzheimer’s disease, as well as respiratory tract infections, cancer, fatigue, heavy metal toxicity, and preventing a condition in which the body tissues do not receive enough oxygen (hypoxia).

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25888188	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Inflammation 102 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25888188	Primary	Basic research	Unknown Approved Use Unknown
Alzheimer’s disease 272 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22482077 https://www.ncbi.nlm.nih.gov/pubmed/21785188	Primary	Preclinical	Unknown Approved Use Unknown
Eczema 46 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21931500	Primary	Phase I 428	Unknown Approved Use Unknown
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27177083	Primary	Basic research	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
AEchem Scientific Corp., USA	AE113297	http://www.aechemsc.com/info_products/AE113297.php
Alichem	119002037	http://www.alichem.com/en/products/479-66-3.html
Ambeed	A425634	https://www.ambeed.com/products/479-66-3.html
Ambinter	Amb22410181	http://www.ambinter.com/reference/22410181
Aurora Fine Chemicals LLC	K16.324.277	http://online.aurorafinechemicals.com/info?ID=K16.324.277
BLD Pharm	BD131622	http://www.bldpharm.com/products/479-66-3.html
BOC Sciences	479-66-3	https://www.bocsci.com/fulvic-acid-cas-479-66-3-item-69440.html
ChemMol	49415093	http://www.chemmol.com/chemmol/49415093.html
ChemMol	99089466	http://www.chemmol.com/chemmol/99089466.html
Chemspace	CSSB00020675406	https://chem-space.com/CSSB00020675406
China MainChem Co., Ltd	479-66-3	https://www.mainchem.com/product/china-fulvic-acid-cas-479-66-3-supplier/
Clearsynth	CS-T-76516	https://www.clearsynth.com/en/CST76516.html
Hello Bio	HB3900	https://www.hellobio.com/fulvic-acid.html
Lab Network	LN01288106	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01288106
MolPort	MolPort-001-739-601	https://www.molport.com/shop/molecule-link/MolPort-001-739-601
MuseChem	R062551	https://www.musechem.com/product/R062551.html
OChem	11150	http://www.ocheminc.com/index.php?act=psearch&pid=479F663
Sigma-Aldrich	CDS025195_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/cds025195?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S619494	https://www.smolecule.com/products/s619494
THE BioTek	bt-337622	https://www.thebiotek.com/product/others/bt-337622
Yuhao Chemical	LQ0883	http://www.chemyuhao.com/479-66-3.html
abcr GmbH	AB511574	http://www.abcr.com/shop/en/AB511574
eNovation Chemicals	D589837	http://www.enovationchem.com/productDetails.asp?productID=D589837
eNovation Chemicals	D772640	https://www.enovationchem.com/ProductDetails.asp?ProductID=D772640
iChemical	EBD54100	http://www.ichemical.com/products/479-66-3.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed
Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: an animal model study of Kashin-Beck disease.	1993	8291220
Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease.	1993 Feb 1	8435081
The role of humic substances in drinking water in Kashin-Beck disease in China.	1999 Apr	10090708
Influence of fulvic acid on the collagen secretion of bovine chondrocytes in vitro.	1999 Jul	10398891
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease.	2011	21785188
Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid.	2011 Mar	21331654
The effect of fulvic acid on pre- and postaggregation state of Aβ(17-42): molecular dynamics simulation studies.	2013 Jan	22940640
Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs.	2013 Oct 28	24191153
Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections.	2013 Sep 24	24063298
Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes.	2015 Mar 13	25888188
Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens.	2015 Oct	26406424

Patents

Sample Use Guides

In Vivo Use Guide

Fulvic Acid comes in liquid and powder form: The recommended maintenance dose of Fulvic acid is 1 - 2 Ounces per day based on one teaspoon per 20 pounds (preferably split ½ in the morning and ½ in the mid-afternoon) – 6 teaspoons = 1 ounce = 2 Tablespoons.

Route of Administration: Oral

In Vitro Use Guide

To test the effects of Fulvic acid (FA) on homocysteine-induced COX-2 expression in monocytes, human primary monocytes and U937 cells were pretreated with FA at concentrations of 0.5, 1, 5, and 10 ug/mL for 4 h, and then stimulated with homocysteine (200 uM) for 4 h in the presence of FA. Pretreating monocytes with FA at a concentration of 1 or 10 ug/mL reduced the homocysteine-induced PGE2 secretion.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:26:33 UTC 2023` Edited by `admin` on `Sat Dec 16 01:26:33 UTC 2023`
Record UNII	XII14C5FXV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FULVIC ACID

Official Name

English

FULVIC ACID, (±)-

Common Name

English

FULVIC ACID [INCI]

Brand Name

English

FULVIC ACID [VANDF]

Common Name

English

(±)-FULVIC ACID

Systematic Name

English

1H,3H-PYRANO(4,3-B)(1)BENZOPYRAN-9-CARBOXYLIC ACID, 4,10-DIHYDRO-3,7,8-TRIHYDROXY-3-METHYL-10-OXO-

Common Name

English

1H,10H-PYRANO(4,3-B)(1)BENZOPYRAN-9-CARBOXYLIC ACID, 3,4-DIHYDRO-3,7,8-TRIHYDROXY-3-METHYL-10-OXO-

Common Name

English

Fulvic acid [WHO-DD]

Common Name

English

MIYAMONTE FULVIC ACID

Brand Name

English

Classification Tree Code System Code

DSLD

1807 (Number of products:114)