ETHENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11NO2
Molecular Weight	165.1891
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=CC=CC=C1C(N)=O

InChI

InChIKey=SBNKFTQSBPKMBZ-UHFFFAOYSA-N

InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)

HIDE SMILES / InChI

Description
Sources: http://www.med.or.jp/english/pdf/2001_08/364_368.pdf

Ethenzamide is an anti-inflammatory agent that was used for the treatment of common cold in Japan (in combinations with other NSAIDs).

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Common cold 58 Sources: http://www.med.or.jp/english/pdf/2001_08/364_368.pdf	Primary		Approved 8583	NARON ACE Approved Use Unknown

F_unbound

Value	Dose	Co-administered	Analyte	Population
100% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16394537/			ETHENZAMIDE unknown	Homo sapiens

Doses

Dose	Population	Adverse events
500 mg single, oral Studied dose Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/8807239/	unhealthy Health Status: unhealthy Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8807239/	Other AEs: Eruption... Other AEs: Eruption (1 pt) Sources: https://pubmed.ncbi.nlm.nih.gov/8807239/

AEs

AE	Significance	Dose	Population
Eruption	1 pt	500 mg single, oral Studied dose Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/8807239/	unhealthy Health Status: unhealthy Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8807239/

PubMed

Title	Date	PubMed
Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method.	2010-07	22247865
Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework.	2010-06-15	20529913
Ethenzamide-gentisic acid-acetic acid (2/1/1).	2010-04-10	21579106
Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method.	2010-04	22247849
(13)C Solid-state NMR chromatography by magic angle spinning (1)H T(1) relaxation ordered spectroscopy.	2010-02	19900827
Development of theophylline floating microballoons using cellulose acetate butyrate and/or Eudragit RL 100 polymers with different permeability characteristics.	2010-01	21589766
Herringbone array of hydrogen-bonded ribbons in 2-ethoxybenzamide from high-resolution X-ray powder diffraction.	2009-11	19893241
Photodegradation of pharmaceuticals and personal care products during UV and UV/H2O2 treatments.	2009-10	19712957
Theophylline-gentisic acid (1/1).	2009-08-08	21577539
Distribution of ethenzamide and other ingredients on granule surfaces studied by Raman microspectroscopy and mapping.	2009-05	19530442
Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination.	2009-01-15	19146691
Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage.	2008-09-01	18800500
One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier.	2007-07-31	17582644
Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling.	2006-03-27	16427749
Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose.	2006-03-09	16434157
Dissolution characteristics of cylindrical particles and tablets.	2006-03-09	16414218
Continuous grinding kinetics of ethenzamide particles by fluidized-bed jet-milling.	2006-03	16556539
Influences of drugs on the oxygen uptake rate and biosorption of activated sludge.	2006-01	16394537
Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling.	2005-12	16327240
Effect of particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling on cohesiveness.	2005-05	15793798
Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography.	2005-03-09	15740912
Salicylic acid-induced inactivation of creatine kinase in the presence of lactoperoxidase and H2O2.	2005-01-15	15698578
Grinding-induced equimolar complex formation between thiourea and ethenzamide.	2004-05	15133201
In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method.	2004-03	15018980
Assessment of tableting properties using infinitesimal quantities of powdered medicine.	2003-09-16	12954193
Cutaneous drug reaction case reports: from the world literature.	2003	12688840
Preparation of solid dispersion for ethenzamide-carbopol and theophylline-carbopol systems using a twin screw extruder.	2002-06	12045335
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.	2002-05	11977112
Preparation and clinical application of 2% diflunisal oral ointment for painful lesions of the oral mucosa.	2001-11	11725552
Determination of plasma bromvalerylurea and its main metabolite by a simple high-performance liquid chromatographic method and quantitation of bromide by energy dispersive X-ray spectrometry in carbon tetrachloride-intoxicated rats.	2001-08-15	11499491
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.	1999-01-08	10077225

Patents

Sample Use Guides

In Vivo Use Guide

2 pills containing 84 mg of ethenzamide 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

ETHENZAMIDE

Official Name

English

J3.352I

Preferred Name

English

Ethenzamide [WHO-DD]

Common Name

English

ETHENZAMIDE [MI]

Common Name

English

ETHENZAMIDE [JAN]

Common Name

English

O-ETHOXYBENZAMIDE

Common Name

English

ETENZAMIDE

Common Name

English

NSC-28787

Code

English

ethenzamide [INN]

Common Name

English

ETHOXYBENZAMIDE

Systematic Name

English

ETHENZAMIDE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N02BA77