Nifurmazole, a 5-nitrofuran derivative, is an antibacterial agent. It was used for controlling Salmonella choleraesuis in swine. The mode of action of 5-nitrofuran analogues is based on red-ox biotransformation. Nifurmazole is active against Trypanosoma equiperdum, Schizotrypanum cruzi and Trypanosoma gambiense. Nifurmazole was shown to be somewhat effective againstT. cruzi infection in mice.

Biclotymol, a phenolic antiseptic has multiple actions: it has bacteriostatic, bactericidal, anti-inflammatory and analgesic activity. Biclotymol is recommended as a prompt, effective and safe first-line option for the treatment of sore throat.

Nifuradene (NF-246), a chemotherapeutic nitrofuran, was first synthesized and reported in 1956. Nifuradene, a 5-Nitorofuran derivative, is an antibacterial drug. Early in vitro testing found it an effective chemotherapeutic agent against most of the common urinary pathogens. Subsequent in vivo studies found that this compound is well absorbed after oral administration in both animals and humans. Nifuradene was used for the treatment of urinary tract infections. The over-all cure rate was found to be best at doses exceeding 600 mg a day.

Nibroxane, 5-bromo-2-methyl-5-nitro-m-dioxane, is a topically effective antimicrobial agent with a broad spectrum of activity. Nibroxane is unusual in that it not only possesses high microbiocidal activity against Gram positive (Staphylococcus uureus) and Gram negative (Pseudomonas aeruginosa) bacteria but also against yeasts (Candida albicans) and moulds (Aspergillus niger). In addition, the 5-bromo-5-nitro-m-dioxanes have, as a class of compounds, the distinct advantage of being chemically stable over a wide pH range. This inherent stability, coupled with its broad spectrum of microbiocidal activity, makes nibroxane an excellent candidate as a preservative for cosmetic and pharmaceutical formulations.

Gloxazone is a drug tested against anaplasmosis and cowdriosis, both tick-borne diseases. It was found to cause toxicity in the kidneys of rats and also had unacceptably high toxic levels in lactating cattle.

Lopobutan is an antiseptic agent.

Monalazone is a sulfonylbenzoic acid derivative used as vaginal disinfectant or antiseptic and spermicidal contraceptive.

Penoctonium, a chemotherapeutic agent was used in microbial studies. However, information about the further development of this compound is not available.