| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H8BrNO4 |
| Molecular Weight | 226.025 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1OCC(Br)(CO1)[N+]([O-])=O
InChI
InChIKey=VFBSFSGHILWWIJ-UHFFFAOYSA-N
InChI=1S/C5H8BrNO4/c1-4-10-2-5(6,3-11-4)7(8)9/h4H,2-3H2,1H3
| Molecular Formula | C5H8BrNO4 |
| Molecular Weight | 226.025 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Nibroxane, 5-bromo-2-methyl-5-nitro-m-dioxane, is a topically effective antimicrobial agent with a broad spectrum of activity. Nibroxane is unusual in that it not only possesses high microbiocidal activity against Gram positive (Staphylococcus uureus) and Gram negative (Pseudomonas aeruginosa) bacteria
but also against yeasts (Candida albicans) and moulds (Aspergillus niger). In addition, the 5-bromo-5-nitro-m-dioxanes have, as a class of compounds, the distinct advantage of being chemically stable over a wide pH range. This inherent stability,
coupled with its broad spectrum of microbiocidal activity, makes nibroxane an excellent candidate as a preservative for cosmetic and pharmaceutical formulations.
Approval Year
PubMed
Sample Use Guides
In study in vivo, nibroxane (200 mg/kg, approx. the LD50) was administered orally to rats
Route of Administration:
Oral
The study of plasma concentrations by the g.l.c. method revealed a rapid debromination of nibroxane in vitro to 2-methyl-5-nitro-m-dioxane. To determine the rate of this conversion, nibroxane (500 ng/ml) in rat plasma was incubated, samples removed and analysed by g.l.c. at times from 1 to 60 min.
