Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H8BrNO4 |
Molecular Weight | 226.025 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1OCC(Br)(CO1)[N+]([O-])=O
InChI
InChIKey=VFBSFSGHILWWIJ-UHFFFAOYSA-N
InChI=1S/C5H8BrNO4/c1-4-10-2-5(6,3-11-4)7(8)9/h4H,2-3H2,1H3
Molecular Formula | C5H8BrNO4 |
Molecular Weight | 226.025 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/695693
Sources: https://www.ncbi.nlm.nih.gov/pubmed/695693
Nibroxane, 5-bromo-2-methyl-5-nitro-m-dioxane, is a topically effective antimicrobial agent with a broad spectrum of activity. Nibroxane is unusual in that it not only possesses high microbiocidal activity against Gram positive (Staphylococcus uureus) and Gram negative (Pseudomonas aeruginosa) bacteria
but also against yeasts (Candida albicans) and moulds (Aspergillus niger). In addition, the 5-bromo-5-nitro-m-dioxanes have, as a class of compounds, the distinct advantage of being chemically stable over a wide pH range. This inherent stability,
coupled with its broad spectrum of microbiocidal activity, makes nibroxane an excellent candidate as a preservative for cosmetic and pharmaceutical formulations.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/695693
In study in vivo, nibroxane (200 mg/kg, approx. the LD50) was administered orally to rats
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/695693
The study of plasma concentrations by the g.l.c. method revealed a rapid debromination of nibroxane in vitro to 2-methyl-5-nitro-m-dioxane. To determine the rate of this conversion, nibroxane (500 ng/ml) in rat plasma was incubated, samples removed and analysed by g.l.c. at times from 1 to 60 min.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:56:57 GMT 2023
by
admin
on
Fri Dec 15 18:56:57 GMT 2023
|
Record UNII |
U611CGM1FW
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
EPA PESTICIDE CODE |
116101
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
||
|
NCI_THESAURUS |
C28394
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
290304
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
C84005
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
SUB09219MIG
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
C017556
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
CHEMBL2105156
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
53983-00-9
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
3951
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
U611CGM1FW
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
258-898-7
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
40955
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
DTXSID4042202
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY | |||
|
100000084164
Created by
admin on Fri Dec 15 18:56:57 GMT 2023 , Edited by admin on Fri Dec 15 18:56:57 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |