U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 41 - 50 of 224 results

Status:
Investigational
Source:
INN:nifurvidine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nifurvidine, a 5-nitrofuran derivative, is an antibacterial agent. It was used for controlling Salmonella choleraesuis in swine. The mode of action of 5-nitrofuran analogues is based on red-ox biotransformation.
Status:
Investigational
Source:
INN:dicresulene [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dicresulene is the antiseptic agent. It was used as a hemostatic drug for the control of persistent bleeding.
Status:
Investigational
Source:
INN:debropol [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Debropol is an aliphatic nitro compound, synthesized by The Boots Company. Debropol possesses antimicrobial activity against Pseudomonas aeruginosa.
Status:
Investigational
Source:
INN:pirralkonium bromide
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Pirralkonium is the antiseptic agent.
Status:
Investigational
Source:
NCT01877694: Phase 2 Interventional Completed Bacterial Conjunctivitis
(2013)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Auriclosene (previously known as NVC-422) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. It has been investigated in phase II clinical trials for the treatment of bacterial conjunctivitis and as a topical gel in children with impetigo. In addition, using a guinea pig model was shown, that auriclosene was effective in the treatment of dermatophytosis, including onychomycosis.
Status:
Investigational
Source:
INN:disiquonium chloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Disiquonium is a quaternary ammonium derivative. It was developed as antiseptic agent.
Status:
Investigational
Source:
INN:nifuroquine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nifuroquine is an antibacterial agent, used in the treatment of bovine mastitis.
Status:
Investigational
Source:
NCT00612508: Not Applicable Interventional Completed Contraceptive Usage
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dofamium is the antiseptic agent. It was used for the water sterilization.
Status:
Investigational
Source:
INN:sepazonium chloride
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Sepazonium was studied as a topical anti-infective drug. However, information about the current use of this agent is not available.
Status:
Investigational
Source:
INN:deditonium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Deditonium is an antibacterial compound developed by the French company Centre de Recherches des Laboratoires Diamant. Deditonium is a quaternary ammonium derivative and has a bacteriostatic action at concentrations ranging from 1x10-6 to 5x10-4 M. Gram-positive cocci were found to be the most sensitive as well as many enterobacteria.