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Details

Stereochemistry ACHIRAL
Molecular Formula C4H9Cl2NO3S
Molecular Weight 222.09
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AURICLOSENE

SMILES

CC(C)(CS(O)(=O)=O)N(Cl)Cl

InChI

InChIKey=QYNRGGHZWCUZLK-UHFFFAOYSA-N
InChI=1S/C4H9Cl2NO3S/c1-4(2,7(5)6)3-11(8,9)10/h3H2,1-2H3,(H,8,9,10)

HIDE SMILES / InChI

Molecular Formula C4H9Cl2NO3S
Molecular Weight 222.09
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Auriclosene (previously known as NVC-422) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. It has been investigated in phase II clinical trials for the treatment of bacterial conjunctivitis and as a topical gel in children with impetigo. In addition, using a guinea pig model was shown, that auriclosene was effective in the treatment of dermatophytosis, including onychomycosis.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Ophthalmic solution dispensed as drops onto the eye. Auriclosene Solution 0.3% | Dermal Gel applied 3 times per day for 7 days
Route of Administration: Other
In Vitro Use Guide
NVC-422 (AURICLOSENE) reduced the viral titer of HAdV-5, HAdV-8, HAdV-19, HAdV-37, and HSV-1 by at least 4 logs after 1 hour incubation at 250 μM. Incubation of coxsackievirus A24 and enterovirus 70 with 2.5 mM NVC-422 for 1 hour reduced the viral titer by 4 logs and 4.5 logs, respectively. The virucidal activity of NVC-422 is maintained in the presence of 10% synthetic tears. In the EpiOcular corneal tissue model, NVC-422 was nonirritating at concentrations up to 41 mM.
Substance Class Chemical
Record UNII
BKR7Y95229
Record Status Validated (UNII)
Record Version