Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H8Cl2NO3S.Na |
| Molecular Weight | 244.072 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC(C)(CS([O-])(=O)=O)N(Cl)Cl
InChI
InChIKey=NMHCZZRJHKDTBE-UHFFFAOYSA-M
InChI=1S/C4H9Cl2NO3S.Na/c1-4(2,7(5)6)3-11(8,9)10;/h3H2,1-2H3,(H,8,9,10);/q;+1/p-1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H8Cl2NO3S |
| Molecular Weight | 221.082 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Auriclosene (previously known as NVC-422) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. It has been investigated in phase II clinical trials for the treatment of bacterial conjunctivitis and as a topical gel in children with impetigo. In addition, using a guinea pig model was shown, that auriclosene was effective in the treatment of dermatophytosis, including onychomycosis.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents. | 2009 May 15 |
|
| Gallium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones: antimicrobial and cytotoxic effects and investigation on the interactions with tubulin. | 2013 Feb |
|
| Evaluation of antioxidant and antimicrobial activities of essential oils from Carum copticum seed and Ferula assafoetida latex. | 2013 Feb |
|
| Broad-spectrum virucidal activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against viral ocular pathogens in vitro. | 2013 Feb 19 |
Patents
Sample Use Guides
Ophthalmic solution dispensed as drops onto the eye. Auriclosene Solution 0.3% |
Dermal Gel applied 3 times per day for 7 days
Route of Administration:
Other
NVC-422 (AURICLOSENE) reduced the viral titer of HAdV-5, HAdV-8, HAdV-19, HAdV-37, and HSV-1 by at least 4 logs after 1 hour incubation at 250 μM. Incubation of coxsackievirus A24 and enterovirus 70 with 2.5 mM NVC-422 for 1 hour reduced the viral titer by 4 logs and 4.5 logs, respectively. The virucidal activity of NVC-422 is maintained in the presence of 10% synthetic tears. In the EpiOcular corneal tissue model, NVC-422 was nonirritating at concentrations up to 41 mM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 06:57:28 UTC 2023
by
admin
on
Sat Dec 16 06:57:28 UTC 2023
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| Record UNII |
3L12631G2J
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| Record Status |
Validated (UNII)
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25028238
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| Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
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