Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H8Cl2NO3S.Na.H2O |
| Molecular Weight | 262.087 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[Na+].CC(C)(CS([O-])(=O)=O)N(Cl)Cl
InChI
InChIKey=DZYCRLINOCERBD-UHFFFAOYSA-M
InChI=1S/C4H9Cl2NO3S.Na.H2O/c1-4(2,7(5)6)3-11(8,9)10;;/h3H2,1-2H3,(H,8,9,10);;1H2/q;+1;/p-1
| Molecular Formula | C4H9Cl2NO3S |
| Molecular Weight | 222.09 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Auriclosene (previously known as NVC-422) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. It has been investigated in phase II clinical trials for the treatment of bacterial conjunctivitis and as a topical gel in children with impetigo. In addition, using a guinea pig model was shown, that auriclosene was effective in the treatment of dermatophytosis, including onychomycosis.
Originator
Approval Year
Sample Use Guides
Ophthalmic solution dispensed as drops onto the eye. Auriclosene Solution 0.3% |
Dermal Gel applied 3 times per day for 7 days
Route of Administration:
Other
NVC-422 (AURICLOSENE) reduced the viral titer of HAdV-5, HAdV-8, HAdV-19, HAdV-37, and HSV-1 by at least 4 logs after 1 hour incubation at 250 μM. Incubation of coxsackievirus A24 and enterovirus 70 with 2.5 mM NVC-422 for 1 hour reduced the viral titer by 4 logs and 4.5 logs, respectively. The virucidal activity of NVC-422 is maintained in the presence of 10% synthetic tears. In the EpiOcular corneal tissue model, NVC-422 was nonirritating at concentrations up to 41 mM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:19:56 UTC 2023
by
admin
on
Fri Dec 15 16:19:56 UTC 2023
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| Record UNII |
4787JWS9HN
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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4787JWS9HN
Created by
admin on Fri Dec 15 16:19:56 UTC 2023 , Edited by admin on Fri Dec 15 16:19:56 UTC 2023
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76964366
Created by
admin on Fri Dec 15 16:19:56 UTC 2023 , Edited by admin on Fri Dec 15 16:19:56 UTC 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ANHYDROUS->SOLVATE |
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PARENT -> SALT/SOLVATE |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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