NIFURMAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H10N4O6
Molecular Weight	294.2203
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCN1C(=O)CN(\N=C\C=C\C2=CC=C(O2)[N+]([O-])=O)C1=O

InChI

InChIKey=IKQHXERIXMQWQK-LYTCUFGASA-N

InChI=1S/C11H10N4O6/c16-7-13-9(17)6-14(11(13)18)12-5-1-2-8-3-4-10(21-8)15(19)20/h1-5,16H,6-7H2/b2-1+,12-5+

HIDE SMILES / InChI

Molecular Formula	C11H10N4O6
Molecular Weight	294.2203
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y | https://www.ncbi.nlm.nih.gov/pubmed/29844300 | https://www.ncbi.nlm.nih.gov/pubmed/4987585 | https://www.ncbi.nlm.nih.gov/pubmed/1100423

Nifurmazole, a 5-nitrofuran derivative, is an antibacterial agent. It was used for controlling Salmonella choleraesuis in swine. The mode of action of 5-nitrofuran analogues is based on red-ox biotransformation. Nifurmazole is active against Trypanosoma equiperdum, Schizotrypanum cruzi and Trypanosoma gambiense. Nifurmazole was shown to be somewhat effective againstT. cruzi infection in mice.

Approval Year

PubMed

Title	Date	PubMed
Trypanosoma cruzi: antimicrobial activity and strain differentiating properties of some five- and six-membered heterocyclic compounds on trypomastigotes.	1975 Oct	1100423

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:50 GMT 2023` Edited by `admin` on `Sat Dec 16 16:16:50 GMT 2023`
Record UNII	LOF2A7032C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NIFURMAZOLE

Official Name

English

CB-10615

Code

English

CB 10615

Code

English

nifurmazole [INN]

Common Name

English

3-(HYDROXYMETHYL)-1-((3-(5-NITRO-2-FURYL)ALLYLIDENE)AMINO)HYDANTOIN

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394