BICLOTYMOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H26Cl2O2
Molecular Weight	381.336
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=CC(Cl)=C(C)C(CC2=C(C)C(Cl)=CC(C(C)C)=C2O)=C1O

InChI

InChIKey=HNOOXWDWUSLXOB-UHFFFAOYSA-N

InChI=1S/C21H26Cl2O2/c1-10(2)14-8-18(22)12(5)16(20(14)24)7-17-13(6)19(23)9-15(11(3)4)21(17)25/h8-11,24-25H,7H2,1-6H3

HIDE SMILES / InChI

Molecular Formula	C21H26Cl2O2
Molecular Weight	381.336
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28925466

Biclotymol, a phenolic antiseptic has multiple actions: it has bacteriostatic, bactericidal, anti-inflammatory and analgesic activity. Biclotymol is recommended as a prompt, effective and safe first-line option for the treatment of sore throat.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cell wall disassembly 1 Target ID: GO:0044277 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28925466	Modulator 828

PubMed

Title	Date	PubMed
Overall monotropic behavior of a metastable phase of biclotymol, 2,2'-methylenebis(4-chloro-3-methyl-isopropylphenol), inferred from experimental and topological construction of the related P-T state diagram.	2008 Sep	18200530
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic.	2015 Nov 10	26364713
Role of biclotymol-based products in the treatment of infectious sore throat.	2017 Aug	28925466

Sample Use Guides

In Vivo Use Guide

5-minute application of a 90% biclotymol-based mouthwash (Hexaspray, biclotymol 2.5%, Laboratoires Bouchara Recordati, France) reduced by 5-log the concentration of Pseudomonas aeruginosa strains (data on fle). Similar results were reported for Escherichia coli and Enterococcus strains.

Route of Administration: Irrigation

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:05:19 GMT 2023` Edited by `admin` on `Sat Dec 16 16:05:19 GMT 2023`
Record UNII	W4K0AE8XW9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BICLOTYMOL

Official Name

English

2,2'-METHYLENEBIS(6-CHLOROTHYMOLE)

Common Name

English

Biclotymol [WHO-DD]

Common Name

English

BICLOTYMOL [MART.]

Common Name

English

biclotymol [INN]

Common Name

English

HEXASPRAY

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394