U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H26Cl2O2
Molecular Weight 381.336
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BICLOTYMOL

SMILES

CC(C)C1=CC(Cl)=C(C)C(CC2=C(C)C(Cl)=CC(C(C)C)=C2O)=C1O

InChI

InChIKey=HNOOXWDWUSLXOB-UHFFFAOYSA-N
InChI=1S/C21H26Cl2O2/c1-10(2)14-8-18(22)12(5)16(20(14)24)7-17-13(6)19(23)9-15(11(3)4)21(17)25/h8-11,24-25H,7H2,1-6H3

HIDE SMILES / InChI

Description

Biclotymol, a phenolic antiseptic has multiple actions: it has bacteriostatic, bactericidal, anti-inflammatory and analgesic activity. Biclotymol is recommended as a prompt, effective and safe first-line option for the treatment of sore throat.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
828
PubMed

PubMed

TitleDatePubMed
Overall monotropic behavior of a metastable phase of biclotymol, 2,2'-methylenebis(4-chloro-3-methyl-isopropylphenol), inferred from experimental and topological construction of the related P-T state diagram.
2008 Sep
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic.
2015 Nov 10
Role of biclotymol-based products in the treatment of infectious sore throat.
2017 Aug

Sample Use Guides

In Vivo Use Guide
5-minute application of a 90% biclotymol-based mouthwash (Hexaspray, biclotymol 2.5%, Laboratoires Bouchara Recordati, France) reduced by 5-log the concentration of Pseudomonas aeruginosa strains (data on fle). Similar results were reported for Escherichia coli and Enterococcus strains.
Route of Administration: Irrigation
Name Type Language
BICLOTYMOL
INN   MART.   WHO-DD  
INN  
Official Name English
2,2'-METHYLENEBIS(6-CHLOROTHYMOLE)
Common Name English
Biclotymol [WHO-DD]
Common Name English
BICLOTYMOL [MART.]
Common Name English
biclotymol [INN]
Common Name English
HEXASPRAY
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
Code System Code Type Description
INN
2065
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
WIKIPEDIA
BICLOTYMOL
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID90166144
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107655
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
CAS
15686-33-6
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
FDA UNII
W4K0AE8XW9
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
SMS_ID
100000085880
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
NCI_THESAURUS
C73252
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
EVMPD
SUB05821MIG
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
RXCUI
236268
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
239-771-5
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
PUBCHEM
71878
Created by admin on Sat Dec 16 16:05:19 GMT 2023 , Edited by admin on Sat Dec 16 16:05:19 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of BICLOTYMOL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966