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Restrict the search for
colchicine
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Thiocolchicine is a colchicine-derivative used in the therapy of some diseases and extensively studied in the field of oncological research as antimitotic agent. It is tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors. Thiocolchicine is a potential antitumor agent.
Trimethylcolchicinic acid (also known as deacetyl colchicine) was used for patients with advanced malignancies. However, these studies were discontinued. Expeiments on rat were shown, that trimethylcolchicinic acid was able to improve normal liver histology, ultrastructure, collagen content and biochemical markers of liver damage in spite of that trimethylcolchicinic acid, didn't bind tubulin.
Status:
Possibly Marketed Outside US
Source:
ANDA211519
(1961)
Source URL:
First approved in 1961
Source:
ANDA211519
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Colchiceine, a metabolite of colchicine, commonly used to treat gout, was studied as an effective compound in the model of liver damage.
