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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H21NO5
Molecular Weight 343.3737
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIMETHYLCOLCHICINIC ACID

SMILES

COC1=C(OC)C(OC)=C2C(CC[C@H](N)C3=CC(=O)C(O)=CC=C23)=C1

InChI

InChIKey=IRVWPZRYDQROLU-ZDUSSCGKSA-N
InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1

HIDE SMILES / InChI

Description

Trimethylcolchicinic acid (also known as deacetyl colchicine) was used for patients with advanced malignancies. However, these studies were discontinued. Expeiments on rat were shown, that trimethylcolchicinic acid was able to improve normal liver histology, ultrastructure, collagen content and biochemical markers of liver damage in spite of that trimethylcolchicinic acid, didn't bind tubulin.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
30 μg/L
7 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens
41 μg/L
5 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
490 μg × h/L
7 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens
737 μg × h/L
5 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
9.5 h
7 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens
10.7 h
5 mg/m² 1 times / day multiple, oral
TRIMETHYLCOLCHICINIC ACID plasma
Homo sapiens

Doses

AEs

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Tox targets

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
once daily for 5 days every 3rd week
Route of Administration: Oral
In Vitro Use Guide
Unknown