| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H25NO5S |
| Molecular Weight | 415.503 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(SC)=CC=C23)=C1
InChI
InChIKey=CMEGANPVAXDBPL-INIZCTEOSA-N
InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
Thiocolchicine is a colchicine-derivative used in the therapy of some diseases and extensively studied in the field of oncological research as antimitotic agent. It is tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors. Thiocolchicine is a potential antitumor agent.
Approval Year
PubMed
Patents
Sample Use Guides
for the treatment of Peyronie's Disease: 2mL injection containing 4mg of thiocolchicine, injected using a 0.3x8mm needle in many punctures into the plaque. Thiocolchicine 4mg or verapamil 5mg were given in 7 injections (once a week)
Route of Administration:
Other
SUBSTANCE RECORD
