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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
INN:thyropropic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Thyropropic Acid (also known as Triopron) is a hydrocinnamic acid derivative and naturally occurring thyroid analog with antigoitrogenic and anticholesteremic activity. Thyropropic Acid acts as potent antagonist of thyroid hormone receptors and may be useful in the therapy of resistance to thyroid hormone and corticosteroid-induced skin atrophy. In preclinical models, Thyropropic Acid reduced serum cholesterol 27% and liver incorporation of acetate into cholesterol 37% but did not affect liver cholesterol levels.
Status:
Investigational
Source:
NCT02322086: Phase 2 Interventional Completed Psoriasis
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Rose Bengal lactone is a polyhalogenated derivative of Fluorescein. Rose Bengal lactone is a dye compound described to produce cell membrane damage. Rose Bengal lactone and other Fluorescein derivatives are also described to modulate the function of ATP-sensitive K+ channels. Rose bengal lactone reacts readily with bases so treatment with triethylamine immediately yields the Rose Bengal salt.
Status:
Investigational
Source:
NCT01000233: Phase 2/Phase 3 Interventional Unknown status Heart Valve Disease
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
Arch Geschwulstforsch. 1983;53(1):37-44.: Phase 3 Veterinary clinical trial Completed Sarcoma, Experimental
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Streptonigrin is an antibiotic produced by Streptomyces flocculus. Streptonigrin exhibits activity as a broad spectrum antibiotic against both Gram-positive and Gram-negative bacteria. Streptonigrin shows antitumor activity against sarcomas, carcinomas, leukemias and lymphomas in vivo and in vitro. Due to its high toxicity, streptonigrin has not recieved widespread clinical use.
Status:
Investigational
Source:
NCT04227756: Phase 1 Interventional Completed Healthy
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
INN:iodocetylic acid (¹²³I) [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Iodocetylic Acid I-123 is a radiolabeled derivative of cetylic acid. Iodocetylic Acid I-123 was studied as for in vivo diagnosis of the myocardium.
Status:
Investigational
Source:
NCT01931241: Phase 1 Interventional Unknown status Hypercholesterolemia
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Hyodeoxycholic acid, also known as HDCA, is a secondary bile acid. Natural 6alpha-hydroxylated bile acids are receptor-specific activators of nuclear liver X receptor alpha (LXRalpha), a nuclear receptor regulating the expression of the cholesterol 7alpha-hydroxylase gene. AHRO-001 (Hyodeoxycholic acid) is in phase I clinical trials for the treatment of atherosclerosis. Through a complex signaling processes utilizing LXR receptors, the compound is designed to increase the efficiency of cholesterol efflux using the HDL cells, which act on all cholesterol in the arterial circulation as well as in the lipid core of plaque deposits in the artery walls. Use of AHRO-001 has shown no adverse effects on morbidity, mortality or toxicity and has been well tolerated at high doses.
Status:
Investigational
Source:
INN:cartazolate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Cartazolate (also known as SQ-65,396) is GABAA receptor positive allosteric modulator with potent anxiolytic activity proven in clinical trials. Cartazolate is also known to act as an adenosine antagonist at the A1 and A2 subtypes and as a phosphodiesterase inhibitor.
Class (Stereo):
CHEMICAL (ACHIRAL)
Nihydrazone, a feed additive for chickens, has both antibacterial and antiprotozoal activity. It was found to be effective against coccidiosis due to Eimeria tenella and E. necatrix and it prevented an outbreak of cecal coccidiosis, reduced the incidence of "air sac infection," improved weight gains, feed conversions and livability and, in addition, it was active against fowl typhoid.
Status:
Investigational
Source:
USAN:CLOTICASONE PROPIONATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cloticasone propionate is an ester of an antiinflammation steroid cloticasone.
