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Details

Stereochemistry ACHIRAL
Molecular Formula C15H11I3O4
Molecular Weight 635.9589
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THYROPROPIC ACID

SMILES

OC(=O)CCC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1

InChI

InChIKey=VRORTNGXAKZJML-UHFFFAOYSA-N
InChI=1S/C15H11I3O4/c16-10-7-9(2-3-13(10)19)22-15-11(17)5-8(6-12(15)18)1-4-14(20)21/h2-3,5-7,19H,1,4H2,(H,20,21)

HIDE SMILES / InChI
Thyropropic Acid (also known as Triopron) is a hydrocinnamic acid derivative and naturally occurring thyroid analog with antigoitrogenic and anticholesteremic activity. Thyropropic Acid acts as potent antagonist of thyroid hormone receptors and may be useful in the therapy of resistance to thyroid hormone and corticosteroid-induced skin atrophy. In preclinical models, Thyropropic Acid reduced serum cholesterol 27% and liver incorporation of acetate into cholesterol 37% but did not affect liver cholesterol levels.

Originator

Sources: Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales (1954), 148, 1738-42.

Approval Year

PubMed

PubMed

TitleDatePubMed
Metabolic effects of thyroid hormone derivatives.
2008 Feb
Patents

Patents

Name Type Language
THYROPROPIC ACID
INN   MI  
INN  
Official Name English
THYROPROPIC ACID [MI]
Common Name English
thyropropic acid [INN]
Common Name English
4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOHYDROCINNAMIC ACID
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29703
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
NCI_THESAURUS C1553
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
Code System Code Type Description
MERCK INDEX
m10837
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY Merck Index
INN
904
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
NCI_THESAURUS
C152594
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
PUBCHEM
5804
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID20198998
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
DRUG CENTRAL
3604
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL291053
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
FDA UNII
OK7481S22O
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
EVMPD
SUB10995MIG
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
SMS_ID
100000082152
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY
CAS
51-26-3
Created by admin on Fri Dec 15 15:09:23 GMT 2023 , Edited by admin on Fri Dec 15 15:09:23 GMT 2023
PRIMARY