CARTAZOLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H22N4O2
Molecular Weight	290.3608
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCNC1=C2C=NN(CC)C2=NC=C1C(=O)OCC

InChI

InChIKey=IQNQAOGGWGCROX-UHFFFAOYSA-N

InChI=1S/C15H22N4O2/c1-4-7-8-16-13-11-10-18-19(5-2)14(11)17-9-12(13)15(20)21-6-3/h9-10H,4-8H2,1-3H3,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C15H22N4O2
Molecular Weight	290.3608
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6117154 | https://www.ncbi.nlm.nih.gov/pubmed/6284176 | https://www.ncbi.nlm.nih.gov/pubmed/2829919 | https://www.ncbi.nlm.nih.gov/pubmed/816605

Cartazolate (also known as SQ-65,396) is GABAA receptor positive allosteric modulator with potent anxiolytic activity proven in clinical trials. Cartazolate is also known to act as an adenosine antagonist at the A1 and A2 subtypes and as a phosphodiesterase inhibitor.

Originator

Approval Year

PubMed

Title	Date	PubMed
Biotransformation in the monkey of cartazolate (SQ 65,396), a substituted pyrazolopyridine having anxiolytic activity.	1981-07	6117154

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:46:43 GMT 2025` Edited by `admin` on `Mon Mar 31 17:46:43 GMT 2025`
Record UNII	8K93Z46WPY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARTAZOLATE

Official Name

English

NSC-166873

Preferred Name

English

1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLIC ACID, 4-(BUTYLAMINO)-1-ETHYL-, ETHYL ESTER

Common Name

English

SQ 65396

Code

English

cartazolate [INN]

Common Name

English

CARTAZOLATE [USAN]

Common Name

English

SQ-65396

Code

English

Ethyl 4-(butylamino)-1-ethyl-1H-pyrazolo[3,4-b]-pyridine-5-carboxylate

Systematic Name

English

Code System Code Type Description

INN

3779