Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.9589 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1
InChI
InChIKey=VRORTNGXAKZJML-UHFFFAOYSA-N
InChI=1S/C15H11I3O4/c16-10-7-9(2-3-13(10)19)22-15-11(17)5-8(6-12(15)18)1-4-14(20)21/h2-3,5-7,19H,1,4H2,(H,20,21)
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.9589 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Thyropropic Acid (also known as Triopron) is a hydrocinnamic acid derivative and naturally occurring thyroid analog with antigoitrogenic and anticholesteremic activity. Thyropropic Acid acts as potent antagonist of thyroid hormone receptors and may be useful in the therapy of resistance to thyroid hormone and corticosteroid-induced skin atrophy. In preclinical models, Thyropropic Acid reduced serum cholesterol 27% and liver incorporation of acetate into cholesterol 37% but did not affect liver cholesterol levels.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Molecular dynamics of 3,3',5-triiodo-L-thyronine in model membranes: a spin label study. | 1984 Aug 1 |
|
| Specificity in structure-based drug design: identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase. | 1997 Sep |
|
| Novel nonpeptidic inhibitors of peptide deformylase. | 2000 Sep 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:09:23 GMT 2023
by
admin
on
Fri Dec 15 15:09:23 GMT 2023
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| Record UNII |
OK7481S22O
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| Record Status |
Validated (UNII)
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| Record Version |
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Official Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29703
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NCI_THESAURUS |
C1553
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m10837
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904
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C152594
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5804
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DTXSID20198998
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3604
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CHEMBL291053
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OK7481S22O
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SUB10995MIG
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100000082152
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51-26-3
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| Related Record | Type | Details | ||
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