Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.9589 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1
InChI
InChIKey=VRORTNGXAKZJML-UHFFFAOYSA-N
InChI=1S/C15H11I3O4/c16-10-7-9(2-3-13(10)19)22-15-11(17)5-8(6-12(15)18)1-4-14(20)21/h2-3,5-7,19H,1,4H2,(H,20,21)
| Molecular Formula | C15H11I3O4 |
| Molecular Weight | 635.9589 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Thyropropic Acid (also known as Triopron) is a hydrocinnamic acid derivative and naturally occurring thyroid analog with antigoitrogenic and anticholesteremic activity. Thyropropic Acid acts as potent antagonist of thyroid hormone receptors and may be useful in the therapy of resistance to thyroid hormone and corticosteroid-induced skin atrophy. In preclinical models, Thyropropic Acid reduced serum cholesterol 27% and liver incorporation of acetate into cholesterol 37% but did not affect liver cholesterol levels.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Metabolic effects of thyroid hormone derivatives. | 2008-02 |
|
| Novel nonpeptidic inhibitors of peptide deformylase. | 2000-09-15 |
|
| Specificity in structure-based drug design: identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase. | 1997-09 |
|
| Molecular dynamics of 3,3',5-triiodo-L-thyronine in model membranes: a spin label study. | 1984-08-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:48:23 GMT 2025
by
admin
on
Mon Mar 31 17:48:23 GMT 2025
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| Record UNII |
OK7481S22O
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Official Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29703
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NCI_THESAURUS |
C1553
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| Code System | Code | Type | Description | ||
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m10837
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PRIMARY | Merck Index | ||
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904
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C152594
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5804
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DTXSID20198998
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3604
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CHEMBL291053
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OK7481S22O
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SUB10995MIG
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100000082152
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51-26-3
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
