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Restrict the search for
acetylcholine
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
SEN12333 is a alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
MDL 201012 is a muscarinic M3 receptor antagonist.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Pteropodine is a heterohimbine-type oxindole alkaloid specifically isolated from ‘Cat’s claw’ (Uncaria tomentosa), a plant that has shown cytostatic, anti-inflammatory and antimutagenic properties and is used in traditional medicine to cure a number of diseases. Pteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte but further studies are necessary to elucidate the exact mechanism by which Pteropodine positively modulates muscarinic M1 and 5-HT2 receptor functions. Pteropodine reduced the sister-chromatid exchanges and micronucleated polychromatic erythrocytes production by doxorubicin in mouse, showing a protective effect on the in vivo DNA damage. Pteropodine exhibited a significant pro-apoptotic effect on Medullary thyroid carcinoma cells. Moreover, anti-proliferative effect of pteropodine was demonstrated on the acute lymphoblastic leukaemia cells and ovarian carcinoma cells.
![Structure of rel-N-(5-Chloro-2-pyridinyl)-2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-5,6,8,9-tetrahydrooxepino[4,5-b]pyridine-4-carboxamide](/img/b3f878c8-19ec-15a7-357e-889106987f0b.svg?size=200&context=upzskrrclv)
![Structure of [11C]CHIBA-1001](/img/ff522d69-cd21-45bc-a89f-6b2912d258fa.svg?size=200&context=upzskrrclv)
