U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C9H14N2O2
Molecular Weight 182.2197
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AR-R-17779

SMILES

O=C1NC[C@@]2(CN3CCC2CC3)O1

InChI

InChIKey=TYAGAVRSOFABFO-VIFPVBQESA-N
InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula C9H14N2O2
Molecular Weight 182.2197
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets
PubMed

PubMed

TitleDatePubMed
AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.
1999 Nov
Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.
2003 Jan 24
Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands.
2003 May
Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons.
2003 Nov
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.
2004 Apr 19
A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist.
2004 Sep 17
Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes.
2005 Nov 7
α(7) Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way.
2017
Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.
2019 Apr 10
Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes.
2019 Mar
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:19:04 GMT 2023
Edited
by admin
on Sat Dec 16 14:19:04 GMT 2023
Record UNII
C3VZ57BN3M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AR-R-17779
Code English
SPIRO(1-AZABICYCLO(2.2.2)OCTANE-3,5'-OXAZOLIDIN)-2'-ONE, (3S)-
Systematic Name English
AR-R 17779
Code English
(3S)-SPIRO(1-AZABICYCLO(2.2.2)OCTANE-3,5'-OXAZOLIDIN)-2'-ONE
Systematic Name English
AR-R17779
Code English
Code System Code Type Description
FDA UNII
C3VZ57BN3M
Created by admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
PRIMARY
WIKIPEDIA
AR-R17779
Created by admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
PRIMARY
PUBCHEM
5310971
Created by admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
PRIMARY
CAS
178419-47-1
Created by admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
PRIMARY SCIFINDER
EPA CompTox
DTXSID60415499
Created by admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
AR-R17779 IS A DRUG THAT ACTS AS A POTENT AND SELECTIVE FULL AGONIST FOR THE .ALPHA.7 SUBTYPE OF NEURAL NICOTINIC ACETYLCHOLINE RECEPTORS. IT HAS NOOTROPIC EFFECTS IN ANIMAL STUDIES, BUT ITS EFFECTS DO NOT SUBSTITUTE FOR THOSE OF NICOTINE. IT HAS ALSO RECENTLY BEEN STUDIED AS A POTENTIAL NOVEL TREATMENT FOR ARTHRITIS.
Related Record Type Details
ACTIVE MOIETY