Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H14N2O2 |
| Molecular Weight | 182.2197 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NC[C@@]2(CN3CCC2CC3)O1
InChI
InChIKey=TYAGAVRSOFABFO-VIFPVBQESA-N
InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
| Molecular Formula | C9H14N2O2 |
| Molecular Weight | 182.2197 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine. | 2019-04-10 |
|
| Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes. | 2019-03 |
|
| α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. | 2017 |
|
| Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. | 2005-11-07 |
|
| A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist. | 2004-09-17 |
|
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. | 2004-04-19 |
|
| AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. | 2004-04 |
|
| Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons. | 2003-11 |
|
| Attentional effects of nicotinic agonists in rats. | 2003-06 |
|
| Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. | 2003-05 |
|
| Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens. | 2003-01-24 |
|
| AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. | 1999-11 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 22:59:24 GMT 2025
by
admin
on
Tue Apr 01 22:59:24 GMT 2025
|
| Record UNII |
C3VZ57BN3M
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
Download
| Name | Type | Language | ||
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Code | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Code | English |
| Code System | Code | Type | Description | ||
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C3VZ57BN3M
Created by
admin on Tue Apr 01 22:59:24 GMT 2025 , Edited by admin on Tue Apr 01 22:59:24 GMT 2025
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AR-R17779
Created by
admin on Tue Apr 01 22:59:24 GMT 2025 , Edited by admin on Tue Apr 01 22:59:24 GMT 2025
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5310971
Created by
admin on Tue Apr 01 22:59:24 GMT 2025 , Edited by admin on Tue Apr 01 22:59:24 GMT 2025
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178419-47-1
Created by
admin on Tue Apr 01 22:59:24 GMT 2025 , Edited by admin on Tue Apr 01 22:59:24 GMT 2025
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PRIMARY | SCIFINDER | ||
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DTXSID60415499
Created by
admin on Tue Apr 01 22:59:24 GMT 2025 , Edited by admin on Tue Apr 01 22:59:24 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> AGONIST |
AR-R17779 IS A DRUG THAT ACTS AS A POTENT AND SELECTIVE FULL AGONIST FOR THE .ALPHA.7 SUBTYPE OF NEURAL NICOTINIC ACETYLCHOLINE RECEPTORS. IT HAS NOOTROPIC EFFECTS IN ANIMAL STUDIES, BUT ITS EFFECTS DO NOT SUBSTITUTE FOR THOSE OF NICOTINE. IT HAS ALSO RECENTLY BEEN STUDIED AS A POTENTIAL NOVEL TREATMENT FOR ARTHRITIS.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
