Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H14N2O2 |
| Molecular Weight | 182.2197 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NC[C@@]2(CN3CCC2CC3)O1
InChI
InChIKey=TYAGAVRSOFABFO-VIFPVBQESA-N
InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
| Molecular Formula | C9H14N2O2 |
| Molecular Weight | 182.2197 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. | 1999 Nov |
|
| Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens. | 2003 Jan 24 |
|
| Attentional effects of nicotinic agonists in rats. | 2003 Jun |
|
| Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. | 2003 May |
|
| Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons. | 2003 Nov |
|
| AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. | 2004 Apr |
|
| Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. | 2004 Apr 19 |
|
| A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist. | 2004 Sep 17 |
|
| Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. | 2005 Nov 7 |
|
| α(7) Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. | 2017 |
|
| Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine. | 2019 Apr 10 |
|
| Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes. | 2019 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:19:04 GMT 2023
by
admin
on
Sat Dec 16 14:19:04 GMT 2023
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| Record UNII |
C3VZ57BN3M
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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C3VZ57BN3M
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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AR-R17779
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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5310971
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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178419-47-1
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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PRIMARY | SCIFINDER | ||
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DTXSID60415499
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> AGONIST |
AR-R17779 IS A DRUG THAT ACTS AS A POTENT AND SELECTIVE FULL AGONIST FOR THE .ALPHA.7 SUBTYPE OF NEURAL NICOTINIC ACETYLCHOLINE RECEPTORS. IT HAS NOOTROPIC EFFECTS IN ANIMAL STUDIES, BUT ITS EFFECTS DO NOT SUBSTITUTE FOR THOSE OF NICOTINE. IT HAS ALSO RECENTLY BEEN STUDIED AS A POTENTIAL NOVEL TREATMENT FOR ARTHRITIS.
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
