[11C]CHIBA-1001

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H20N2O2
Molecular Weight	259.3322
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[11CH3]C1=CC=C(OC(=O)N2CCN3CCC2CC3)C=C1

InChI

InChIKey=ARTYZBLKDXNPKZ-BJUDXGSMSA-N

InChI=1S/C15H20N2O2/c1-12-2-4-14(5-3-12)19-15(18)17-11-10-16-8-6-13(17)7-9-16/h2-5,13H,6-11H2,1H3/i1-1

HIDE SMILES / InChI

Molecular Formula	C15H20N2O2
Molecular Weight	259.3322
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:35:42 GMT 2023` Edited by `admin` on `Sat Dec 16 11:35:42 GMT 2023`
Record UNII	BJR66D94J6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

[11C]CHIBA-1001

Common Name

English

CHIBA-1001 C-11

Common Name

English

1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLIC ACID, 4-(METHYL-11C)PHENYL ESTER

Systematic Name

English

4-(METHYL-11C)PHENYL) 1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLATE

Systematic Name

English

Code System Code Type Description

FDA UNII

BJR66D94J6

Created by admin on Sat Dec 16 11:35:42 GMT 2023 , Edited by admin on Sat Dec 16 11:35:42 GMT 2023

PRIMARY

PUBCHEM

25141050

Created by admin on Sat Dec 16 11:35:42 GMT 2023 , Edited by admin on Sat Dec 16 11:35:42 GMT 2023

PRIMARY

CAS

946838-42-2

Created by admin on Sat Dec 16 11:35:42 GMT 2023 , Edited by admin on Sat Dec 16 11:35:42 GMT 2023

PRIMARY

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					P4J1I8C6CX

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7

TARGET->RADIOLIGAND

Amount:

Related Record Type Details


					BJR66D94J6

[11C]CHIBA-1001

ACTIVE MOIETY

Comments:

The distribution of radioactivity in the brain regions after intravenous administration of ( 11 C)CHIBA-1001 was blocked by pretreatment with the selective a7 nAChR agonist SSR180711 (5.0 mg/kg). However, the distribution of ( 11 C)CHIBA-1001 was not altered by pretreatment with the selective a4b2 nAChR agonist A85380 (1.0 mg/kg). Interestingly, the binding of ( 11 C)CHIBA-1001 in the frontal cortex of the monkey brain was significantly decreased by subchronic administration of the N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (0.3 mg/kg, twice a day for 13 days), which is a nonhuman primate model of schizophrenia. Conclusions/Significance: The present findings suggest that ( 11 C)CHIBA-1001 could be a novel useful PET ligand for in vivo.

Amount: