Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C9H14N2O2 |
Molecular Weight | 182.2197 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NC[C@@]2(CN3CCC2CC3)O1
InChI
InChIKey=TYAGAVRSOFABFO-VIFPVBQESA-N
InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4980 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10945867 |
190.0 nM [Ki] | ||
Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16266703 |
6.2 µM [EC50] |
PubMed
Title | Date | PubMed |
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AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. | 1999 Nov |
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Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens. | 2003 Jan 24 |
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Attentional effects of nicotinic agonists in rats. | 2003 Jun |
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Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. | 2003 May |
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Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons. | 2003 Nov |
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AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. | 2004 Apr |
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Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. | 2004 Apr 19 |
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A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist. | 2004 Sep 17 |
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Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. | 2005 Nov 7 |
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α(7) Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. | 2017 |
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Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine. | 2019 Apr 10 |
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Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes. | 2019 Mar |
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C3VZ57BN3M
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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AR-R17779
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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5310971
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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178419-47-1
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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PRIMARY | SCIFINDER | ||
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DTXSID60415499
Created by
admin on Sat Dec 16 14:19:05 GMT 2023 , Edited by admin on Sat Dec 16 14:19:05 GMT 2023
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PRIMARY |
ACTIVE MOIETY