AR-R-17779

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H14N2O2
Molecular Weight	182.2197
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NC[C@@]2(CN3CCC2CC3)O1

InChI

InChIKey=TYAGAVRSOFABFO-VIFPVBQESA-N

InChI=1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuronal acetylcholine receptor protein alpha-7 subunit 78 Target ID: CHEMBL4980 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10945867	Agonist 2752		190.0 nM [Ki]
Neuronal acetylcholine receptor protein alpha-7 subunit 78 Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16266703	Agonist 2752		6.2 µM [EC50]

PubMed

Title	Date	PubMed
Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.	2019-04-10	30971711
Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes.	2019-03	30653770
α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way.	2017	29167641
Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes.	2005-11-07	16266703
A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist.	2004-09-17	15357617
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.	2004-04-19	15050614
AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors.	2004-04	14727003
Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons.	2003-11	12890800
Attentional effects of nicotinic agonists in rats.	2003-06	12763099
Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands.	2003-05	12637951
Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.	2003-01-24	12559371
AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.	1999-11	10780509

Name

Type

Language

AR-R-17779

Code

English

AR-R 17779

Preferred Name

English

SPIRO(1-AZABICYCLO(2.2.2)OCTANE-3,5'-OXAZOLIDIN)-2'-ONE, (3S)-

Systematic Name

English

(3S)-SPIRO(1-AZABICYCLO(2.2.2)OCTANE-3,5'-OXAZOLIDIN)-2'-ONE

Systematic Name

English

AR-R17779

Code

English

Code System Code Type Description

FDA UNII

C3VZ57BN3M