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Details

Stereochemistry ACHIRAL
Molecular Formula C20H25N3O2
Molecular Weight 339.4314
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of WAY-317538

SMILES

O=C(CCCCN1CCOCC1)NC2=CC=C(C=C2)C3=CN=CC=C3

InChI

InChIKey=XCHIZTUBUXZESJ-UHFFFAOYSA-N
InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)

HIDE SMILES / InChI

Molecular Formula C20H25N3O2
Molecular Weight 339.4314
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SEN12333 is a alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P36544
Gene ID: 1139|||89832
Gene Symbol: CHRNA7
Target Organism: Homo sapiens (Human)
1.6 µM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.
2009 Jul 15
Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
2009 May
Patents

Patents

Sample Use Guides

SEN12333 was administered intraperitoneally at the doses of 1, 3, and 10 mg/kg.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:11:59 GMT 2023
Edited
by admin
on Sat Dec 16 14:11:59 GMT 2023
Record UNII
M92TU1EZ75
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
WAY-317538
Common Name English
N-(4-(3-PYRIDINYL)PHENYL)-4-MORPHOLINEPENTANAMIDE
Systematic Name English
4-MORPHOLINEPENTANAMIDE, N-(4-(3-PYRIDINYL)PHENYL)-
Systematic Name English
SEN-12333
Common Name English
Code System Code Type Description
PUBCHEM
45484303
Created by admin on Sat Dec 16 14:11:59 GMT 2023 , Edited by admin on Sat Dec 16 14:11:59 GMT 2023
PRIMARY
CAS
874450-44-9
Created by admin on Sat Dec 16 14:11:59 GMT 2023 , Edited by admin on Sat Dec 16 14:11:59 GMT 2023
PRIMARY SCIFINDER
EPA CompTox
DTXSID30670437
Created by admin on Sat Dec 16 14:11:59 GMT 2023 , Edited by admin on Sat Dec 16 14:11:59 GMT 2023
PRIMARY
FDA UNII
M92TU1EZ75
Created by admin on Sat Dec 16 14:11:59 GMT 2023 , Edited by admin on Sat Dec 16 14:11:59 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
WAY-317538 (SEN-12333) IS A DRUG THAT ACTS AS A POTENT AND SELECTIVE FULL AGONIST FOR THE .ALPHA.7 SUBTYPE OF NEURAL NICOTINIC ACETYLCHOLINE RECEPTORS.
Related Record Type Details
ACTIVE MOIETY